Substituted thiophene carboxamides, process for their preparation and their use as medicaments

ABSTRACT

The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula 
                         
wherein A, and R 1  to R 8c  are defined as in claim  1 , the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula

the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.

The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.

The present application thus relates to the new compounds of the above general formula I, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation and use thereof.

A 1st embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted in each case by one or two C₁₋₃-alkyl groups         optionally substituted by a hydroxy, C₁₋₃-alkoxy, amino,         C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered         cycloalkyleneimino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino or C₁₋₅-alkyloxycarbonylamino groups,         or an aminocarbonyl, C₁₋₃-alkylaminocarbonyl or         di-(C₁₋₃-alkyl)-aminocarbonyl group and one or two methylene         groups of the cycloalkyleneimino moiety not adjacent to the         imino group may be substituted by one or two fluorine atoms or a         hydroxy, C₁₋₃-alkoxy, amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl or —NR^(8c)— group and         additionally a methylene group adjacent to a above-mentioned         —NR^(8c)— group may be replaced by a carbonyl group, or     -   an 5- to 7-membered cycloalkenyleneimino group optionally         substituted by one or two C₁₋₃-alkyl, amino-C₁₋₃-alkyl,         C₁₋₃-alkylamino-C₁₋₃-alkyl, di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyl, a         4- to 7-membered cycloalkyleneimino-C₁₋₃-alkyl,         C₁₋₆-cycloalkylamino-C₁₋₃-alkyl, aryl, aryl-C₁₋₃-alkyl,         heteroaryl, heteroaryl-C₁₋₃-alkyl, aminocarbonyl,         C₁₋₃-alkylaminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl or 4- to         7-membered cycloalkyleneiminocarbonyl groups, while the double         bond is not bound to a nitrogen atom and may be fused to a 5- or         6-membered heteroaryl group, -   R¹ denotes a hydrogen or halogenatom, a C₁₋₃-alkyl or C₁₋₃-alkoxy     group, while the hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy     group may optionally be wholly or partly replaced by fluorine atoms,     a C₂₋₃-alkenyl, C₂₋₃-alkynyl, nitrile, nitro or amino group, -   R² denotes a hydrogen or halogenatom or a C₁₋₃-alkyl group, -   R³ denotes a hydrogen atom or a C₁₋₃-alkyl group, -   R⁴ and R⁵ in each case independently of one another denote     -   a hydrogen atom, a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             nitrile, hydroxy, a C₁₋₅-alkyloxy group, while the hydrogen             atoms of the C₁₋₅-alkyloxy group may optionally be wholly or             partly replaced by fluorine atoms, an allyloxy,             propargyloxy, benzyloxy, C₁₋₅-alkylcarbonyloxy,             C₁₋₅-alkyloxycarbonyloxy, carboxy-C₁₋₅-alkyloxy,             C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyloxy, mercapto,             C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl, carboxy,             C₁₋₅-alkyloxycarbonyl, aminocarbonyl,             C₁₋₅-alkylaminocarbonyl, di-(C₁₋₅-alkyl)-aminocarbonyl,             C₃₋₆-cycloalkyleneiminocarbonyl, aminosulphonyl,             C₁₋₅-alkylaminosulphonyl, di-(C₁₋₅-alkyl)-aminosulphonyl,             C₃₋₆-cycloalkyleneiminosulphonyl, amino, C₁₋₅-alkylamino,             di-(C₁₋₅-alkyl)-amino, C₁₋₅-alkylcarbonylamino or             C₁₋₅-alkylsulphonylamino group,     -   a carboxy, aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         C₃₋₆-cycloalkylaminocarbonyl, di-(C₁₋₅-alkyl)-aminocarbonyl,         C₁₋₅-alkoxycarbonyl, C₄₋₆-cycloalkyleneiminocarbonyl group,     -   a phenyl, heteroaryl, phenyl-C₁₋₅-alkyl or heteroaryl-C₁₋₅-alkyl         group,         -   which may optionally be mono- to trisubstituted in the             phenyl or heteroaryl moiety by identical or different             substituents selected from the group consisting of halogen             atoms, C₁₋₅-alkyl, di-(C₁₋₅-alkyl)-amino, hydroxy,             C₁₋₅-alkyloxy, mono-, di- or trifluoromethoxy, carboxy and             C₁₋₅-alkyloxycarbonyl groups,     -   a 3- to 7-membered cycloalkyl, cycloalkyleneimino,         cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group,         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety a methylene group may optionally be replaced by an             —N(R^(8c))— group, an oxygen or sulphur atom or a —S(O) or             —S(O)₂ group, or         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety two adjacent methylene groups may together optionally             be replaced by a —C(O)N(R^(8b))— or —S(O)₂N(R^(8b))— group,             or         -   wherein in 6- to 7-membered cyclic groups in the cyclic             moiety three adjacent methylene groups may optionally be             replaced together by a substituted —OC(O)N(R^(8b))— or             —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,         -   with the proviso that a 3- to 7-membered cycloalkyl,             cycloalkyleneimino, cycloalkyl-C₁₋₅-alkyl or             cycloalkyleneimino-C₁₋₃-alkyl group as hereinbefore defined             wherein two heteroatoms selected from among oxygen and             nitrogen are separated from one another by precisely one             optionally substituted —CH₂— group, is excluded,         -   while a 3- to 7-membered cycloalkyl, cycloalkyleneimino,             cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group             as hereinbefore defined may be substituted at one or two             —CH₂— groups by one or two C₁₋₃-alkyl groups in each case,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl group may         be replaced by an oxygen or sulphur atom or an —N(R^(8c))—, or a         carbonyl, sulphinyl or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may be replaced together by a —C(O)N(R^(8b))— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may be replaced together by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b)) group,     -   while each of the carbon atoms of a C₃₋₈-cycloalkyl group may         optionally be substituted independently of one another by in         each case one or two identical or different halogen atoms or         C₁₋₅-alkyl, nitrile, hydroxy, C₁₋₅-alkyloxy,         C₁₋₅-alkylcarbonyloxy, carboxy-C₁₋₅-alkyl,         C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl, C₁₋₅-alkylsulphanyl,         C₁₋₅-alkylsulphonyl, carboxy, C₁₋₅-alkyloxycarbonyl,         aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         di-(C₁₋₅-alkyl)-aminocarbonyl, C₃₋₆-cycloalkyleneiminocarbonyl,         aminosulphonyl, C₁₋₅-alkylaminosulphonyl,         di-(C₁₋₅-alkyl)-aminosulphonyl,         C₃₋₆-cycloalkyleneiminosulphonyl, amino, C₁₋₅-alkylamino,         di-(C₁₋₅-alkyl)-amino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino groups,     -   while each of the carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally be substituted independently of one another by in         each case one or two identical or different C₁₋₅-alkyl, nitrile,         carboxy-C₁₋₅-alkyl, C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl, carboxy,         C₁₋₅-alkyloxycarbonyl, aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         di-(C₁₋₅-alkyl)-aminocarbonyl, C₃₋₆-cycloalkyleneiminocarbonyl,         aminosulphonyl, C₁₋₅-alkylaminosulphonyl,         di-(C₁₋₅-alkyl)-aminosulphonyl, C₃₋₆-cycloalkyleneiminosulphonyl         group,     -   and each of the carbon atoms of a C₄₋₈-cycloalkenyl group which         are not bound to another carbon atom by a double bond may         optionally be substituted independently of one another by two         identical or different fluorine atoms or hydroxy, C₁₋₅-alkyloxy,         C₁₋₅-alkylcarbonyloxy, C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl,         amino, C₁₋₅-alkylamino, di-(C₁₋₅-alkyl)-amino,         C₁₋₅-alkylcarbonylamino, C₁₋₅-alkylsulphonylamino groups,     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind, formed from R⁴ and R⁵ together,         -   wherein two heteroatoms in the cyclic group selected from             among oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound, are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group, which is             characterised in that a heteroatom selected from among an             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are joined together directly,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a nitrile     group, a C₁₋₃-alkyl or a C₁₋₃-alkoxy group, while the hydrogen atoms     of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or     partly replaced by fluorine atoms, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₅-alkyl, C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or     C₁₋₅-alkylsulphonyl group,     while, unless otherwise stated, by the term “heteroaryl group”     mentioned hereinbefore in the definitions is meant a monocyclic 5-     or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, or an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a 4- to 7-membered         cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group, or an         oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group, and two or three nitrogen atoms,     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the foregoing definitions which have more than two carbon atoms,         unless otherwise stated, may be straight-chain or branched and         the alkyl groups in the previously mentioned dialkylated groups,         for example the dialkylamino groups, may be identical or         different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions may be wholly or partly replaced by         fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

Examples of monocyclic heteroaryl groups are the pyridyl, N-oxy-pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, [1,2,3]triazinyl, [1,3,5]triazinyl, [1,2,4]triazinyl, pyrrolyl, imidazolyl, [1,2,4]triazolyl, [1,2,3]triazolyl, tetrazolyl, furanyl, isoxazolyl, oxazolyl, [1,2,3]oxadiazolyl, [1,2,4]oxadiazolyl, furazanyl, thiophenyl, thiazolyl, isothiazolyl, [1,2,3]thiadiazolyl, [1,2,4]thiadiazolyl or [1,2,5]thiadiazolyl group.

Examples of bicyclic heteroaryl groups are the benzimidazolyl, benzofuranyl, benzo[c]furanyl, benzothiophenyl, benzo[c]thiophenyl, benzothiazolyl, benzo[c]-isothiazolyl, benzo[d]isothiazolyl, benzoxazolyl, benzo[c]isoxazolyl, benzo[d]-isoxazolyl, benzo[1,2,5]oxadiazolyl, benzo[1,2,5]thiadiazolyl, benzo[1,2,3]thia-diazolyl, benzo[d][1,2,3]triazinyl, benzo[1,2,4]triazinyl, benzotriazolyl, cinnolinyl, quinolinyl, N-oxy-quinolinyl, isoquinolinyl, quinazolinyl, N-oxy-quinazolinyl, quinoxalinyl, phthalazinyl, indolyl, isoindolyl or 1-oxa-2,3-diaza-indenyl group.

Examples of the C₁₋₆-alkyl groups mentioned hereinbefore in the definitions are the methyl, ethyl, 1-propyl, 2-propyl, n-butyl, sec-butyl, tert-butyl, 1-pentyl, 2-pentyl, 3-pentyl, neo-pentyl, 3-methyl-2-butyl, 1-hexyl, 2-hexyl, 3-hexyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 3-methyl-3-pentyl, 2-methyl-3-pentyl, 2,2-dimethyl-3-butyl or 2,3-dimethyl-2-butyl group.

Examples of the C₁₋₅-alkyloxy groups mentioned hereinbefore in the definitions are the methyloxy, ethyloxy, 1-propyloxy, 2-propyloxy, n-butyloxy, sec-butyloxy, tert-butyloxy, 1-pentyloxy, 2-pentyloxy, 3-pentyloxy or neo-pentyloxy group.

Examples of the C₂₋₆-alkenyl groups mentioned hereinbefore in the definitions are the ethenyl, 1-propen-1-yl, 2-propen-1-yl, 1-buten-1-yl, 2-buten-1-yl, 3-buten-1-yl, 1-penten-1-yl, 2-penten-1-yl, 3-penten-1-yl, 4-penten-1-yl, 1-hexen-1-yl, 2-hexen-1-yl, 3-hexen-1-yl, 4-hexen-1-yl, 5-hexen-1-yl, but-1-en-2-yl, but-2-en-2-yl, but-1-en-3-yl, 2-methyl-prop-2-en-1-yl, pent-1-en-2-yl, pent-2-en-2-yl, pent-3-en-2-yl, pent-4-en-2-yl, pent-1-en-3-yl, pent-2-en-3-yl, 2-methyl-but-1-en-1-yl, 2-methyl-but-2-en-1-yl, 2-methyl-but-3-en-1-yl, 2-ethyl-prop-2-en-1-yl, hex-1-en-2-yl, hex-2-en-2-yl, hex-3-en-2-yl, hex-4-en-2-yl, hex-5-en-2-yl, hex-1-en-3-yl, hex-2-en-3-yl, hex-3-en-3-yl, hex-4-en-3-yl, hex-5-en-3-yl, hex-1-en-4-yl, hex-2-en-4-yl, hex-3-en-4-yl, hex-4-en-4-yl, hex-5-en-4-yl, 4-methyl-pent-1-en-3-yl, 3-methyl-pent-1-en-3-yl, 2-methyl-pent-1-en-3-yl, 2,3-dimethyl-but-1-en-3-yl, 3,3-dimethyl-but-1-en-2-yl or 2-ethyl-but-1-en-3-yl group,

Examples for the C₂₋₆-alkynyl groups mentioned hereinbefore in the definitions are the ethynyl, 1-propynyl, 2-propynyl, 1-butyn-1-yl, 1-butyn-3-yl, 2-butyn-1-yl, 3-butyn-1-yl, 1-pentyn-1-yl, 1-pentyn-3-yl, 1-pentyn-4-yl, 2-pentyn-1-yl, 2-pentyn-3-yl, 3-pentyn-1-yl, 4-pentyn-1-yl, 2-methyl-1-butyn-4-yl, 3-methyl-1-butyn-1-yl, 3-methyl-1-butyn-3-yl, 1-hexyn-1-yl, 2-hexyn-1-yl, 3-hexyn-1-yl, 4-hexyn-1-yl, 5-hexyn-1-yl, 1-hexyn-3-yl, 1-hexyn-4-yl, 1-hexyn-5-yl, 2-hexyn-4-yl, 2-hexyn-5-yl, 3-hexyn-5-yl, 3-methyl-1-pentyn-3-yl, 4-methyl-1-pentyn-3-yl, 3-methyl-1-pentyn-4-yl, 4-methyl-1-pentyn-4-yl, 4-methyl-2-pentyn-4-yl, 4-methyl-2-pentyn-1-yl, 2,2-dimethyl-3-butyn-1-yl or 2-ethyl-3-butyn-1-yl group.

By a group which may be converted in vivo into a carboxy group is meant for example a carboxy group esterified with an alcohol wherein the alcoholic moiety preferably denotes a C₁₋₆-alkanol, a phenyl-C₁₋₃-alkanol, a C₃₋₉-cycloalkanol, a C₅₋₇-cycloalkenol, a C₃₋₅-alkenol, a phenyl-C₃₋₅-alkenol, a C₃₋₅-alkynol or phenyl-C₃₋₅-alkynol, with the proviso that no bond to the oxygen atom starts from a carbon atom which carries a double or triple bond, a C₃₋₈-cycloalkyl-C₁₋₃-alkanol or an alcohol of formula R⁹—CO—O—(R¹⁰CR¹¹)—OH, wherein

-   -   R⁹ denotes a C₁₋₈-alkyl, C₅₋₇-cycloalkyl, phenyl or         phenyl-C₁₋₃-alkyl group,     -   R¹⁰ denotes a hydrogen atom, a C₁₋₃-alkyl, C₅₋₇-cycloalkyl or         phenyl group and     -   R¹¹ denotes a hydrogen atom or a C₁₋₃-alkyl group.

Preferred groups which may be cleaved from a carboxy group in vivo include a C₁₋₆-alkoxy group such as the methoxy, ethoxy, n-propyloxy, isopropyloxy, n-butyloxy, n-pentyloxy, n-hexyloxy or cyclohexyloxy group or a phenyl-C₁₋₃-alkoxy group such as the benzyloxy group.

By a group which may be converted in vivo into a hydroxyl group is meant for example a hydroxyl group esterified with a carboxylic acid wherein the carboxylic acid moiety is preferably a C₁₋₇-alkanoic acid, a phenyl-C₁₋₃-alkanoic acid, a C₃₋₉-cycloalkylcarboxylic acid, a C₅₋₇-cycloalkenecarboxylic acid, a C₃₋₇-alkenoic acid, a phenyl-C₃₋₅-alkenoic acid, a C₃₋₇-alkynoic acid or phenyl-C₃₋₅-alkynoic acid, while individual methylene groups of the carboxylic acid group may be replaced by oxygen atoms, with the proviso that no bond to the oxygen atom starts from a carbon atom which carries a double or triple bond.

Examples of preferred groups which may be cleaved in vivo from a hydroxyl group include a C₁₋₇-acyl group such as the formyl, acetyl, n-propionyl, isopropionyl, n-propanoyl, n-butanoyl, n-pentanoyl, n-hexanoyl or cyclohexylcarbonyl group or a benzoyl group and also a methoxyacetyl, 1-methoxypropionyl, 2-methoxypropionyl or 2-methoxy-ethoxyacetyl group.

The compounds of general formula I, wherein A, R⁴ and/or R⁵ contains a group which may be converted in vivo into a carboxy or hydroxyl group are prodrugs for those compounds of general formula I wherein A, R⁴ and/or R⁵ contains a carboxy or hydroxyl group.

A 2nd embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted in each case by one or two C₁₋₃-alkyl groups         optionally substituted by a hydroxy, C₁₋₃-alkoxy, amino,         C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered         cycloalkyleneimino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino or C₁₋₅-alkyloxycarbonylamino groups or         an aminocarbonyl, C₁₋₃-alkylaminocarbonyl or         di-(C₁₋₃-alkyl)-aminocarbonyl group and one or two methylene         groups of the cycloalkyleneimino moiety not adjacent to the         imino group may be substituted by one or two fluorine atoms or a         hydroxy, C₁₋₃-alkoxy, amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen atom or by         a —NR^(8c)— group and additionally a methylene group adjacent to         an above-mentioned —NR^(8c)— group may be replaced by a carbonyl         group, or     -   an 5- to 7-membered cycloalkenyleneimino group optionally         substituted by one or two C₁₋₃-alkyl, amino-C₁₋₃-alkyl,         C₁₋₃-alkylamino-C₁₋₃-alkyl, di-(C₁₋₃-alkyl)-amino-C₁₋₃-alkyl, a         4- to 7-membered cycloalkyleneimino-C₁₋₃-alkyl,         C₁₋₆-cycloalkylamino-C₁₋₃-alkyl, aryl, aryl-C₁₋₃-alkyl,         heteroaryl, heteroaryl-C₁₋₃-alkyl, aminocarbonyl,         C₁₋₃-alkylaminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl or 4- to         7-membered cycloalkyleneiminocarbonyl groups, while the double         bond is not bound to a nitrogen atom and may be fused to a 5- or         6-membered heteroaryl group, -   R¹ denotes a fluorine, chlorine, bromine or iodine atom, a     C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the     C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly     replaced by fluorine atoms, or a nitrile group, -   R² denotes a hydrogen or halogenatom or a methyl group, -   R³ denotes a hydrogen atom or a C₁₋₃-alkyl group, -   R⁴ denotes a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             nitrile, hydroxy, a C₁₋₅-alkyloxy group,         -   while the hydrogen atoms of the C₁₋₅-alkyloxy group may             optionally be wholly or partly replaced by fluorine atoms, a             benzyloxy, C₁₋₅-alkylcarbonyloxy, C₁₋₅-alkyloxycarbonyloxy,             carboxy-C₁₋₅-alkyloxy, C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyloxy,             C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl, carboxy,             C₁₋₅-alkyloxycarbonyl, aminocarbonyl,             C₁₋₅-alkylaminocarbonyl, di-(C₁₋₅-alkyl)-aminocarbonyl,             C₃₋₆-cycloalkyleneiminocarbonyl, aminosulphonyl,             C₁₋₅-alkylaminosulphonyl, di-(C₁₋₅-alkyl)-aminosulphonyl,             C₃₋₆-cycloalkyleneiminosulphonyl, amino, C₁₋₅-alkylamino,             di-(C₁₋₅-alkyl)-amino, C₁₋₅-alkylcarbonylamino or             C₁₋₅-alkylsulphonylamino group,     -   a carboxy, aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         C₃₋₆-cycloalkylamino-carbonyl, di-(C₁₋₅-alkyl)-aminocarbonyl,         C₁₋₅-alkoxycarbonyl, C₄₋₆-cycloalkyleneiminocarbonyl group,     -   a phenyl, heteroaryl, phenyl-C₁₋₅-alkyl or heteroaryl-C₁₋₅-alkyl         group, which may optionally be mono- to trisubstituted in the         phenyl or heteroaryl moiety by identical or different         substituents selected from the group consisting of halogen         atoms, C₁₋₅-alkyl, di-(C₁₋₅-alkyl)-amino, hydroxy,         C₁₋₅-alkyloxy, mono-, di- or trifluoromethoxy, carboxy- and         C₁₋₅-alkyloxycarbonyl groups,     -   a 3- to 7-membered cycloalkyl, cycloalkyleneimino,         cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group,         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety a methylene group may optionally be replaced by a             —N(R^(8c))— group, an oxygen or sulphur atom or a —S(O) or             —S(O)₂ group, or         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety two adjacent methylene groups may together optionally             be replaced by a —C(O)N(R^(8b))— or —S(O)₂N(R^(8b))— group,             or     -   wherein in 6- to 7-membered cyclic groups in the cyclic moiety         three adjacent methylene groups may together optionally be         replaced by a substituted —OC(O)N(R^(8b))— or         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   with the proviso that a 3- to 7-membered cycloalkyl,         cycloalkyleneimino, cycloalkyl-C₁₋₅-alkyl or         cycloalkyleneimino-C₁₋₃-alkyl group as hereinbefore defined         wherein two heteroatoms from the group oxygen and nitrogen are         separated from one another by precisely one optionally         substituted —CH₂— group, is excluded,     -   while a 3- to 7-membered cycloalkyl, cycloalkyleneimino,         cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group as         hereinbefore defined may be substituted at one or two —CH₂—         groups in each case by one or two C₁₋₃-alkyl groups, -   R⁵ denotes a hydrogen atom, a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₅-alkyloxy group, while the hydrogen atoms of the             C₁₋₅-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl group may         be replaced by an oxygen atom or a —N(R^(8c))—, or a carbonyl,         or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while each of the carbon atoms of a C₃₋₈-cycloalkyl group may         optionally be substituted independently of one another by in         each case one or two identical or different halogen atoms or         C₁₋₅-alkyl, nitrile, hydroxy, C₁₋₅-alkyloxy,         C₁₋₅-alkylcarbonyloxy, carboxy-C₁₋₅-alkyl,         C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl, C₁₋₅-alkylsulphanyl,         C₁₋₅-alkylsulphonyl, carboxy, C₁₋₅-alkyloxycarbonyl,         aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         di-(C₁₋₅-alkyl)-aminocarbonyl, C₃₋₆-cycloalkyleneiminocarbonyl,         aminosulphonyl, C₁₋₅-alkylaminosulphonyl,         di-(C₁₋₅-alkyl)-aminosulphonyl,         C₃₋₆-cycloalkyleneiminosulphonyl, amino, C₁₋₅-alkylamino,         di-(C₁₋₅-alkyl)-amino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino groups,     -   while each of the carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally be substituted independently of one another by in         each case one or two identical or different C₁₋₅-alkyl, nitrile,         carboxy-C₁₋₅-alkyl, C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl, carboxy,         C₁₋₅-alkyloxycarbonyl, aminocarbonyl, C₁₋₅-alkylaminocarbonyl,         di-(C₁₋₅-alkyl)-aminocarbonyl, C₃₋₆-cycloalkyleneiminocarbonyl,         aminosulphonyl, C₁₋₅-alkylaminosulphonyl,         di-(C₁₋₅-alkyl)-aminosulphonyl, C₃₋₆-cycloalkyleneiminosulphonyl         groups,     -   and each of the carbon atoms of a C₄₋₈-cycloalkenyl group which         are not bound to another carbon atom by a double bond, may         optionally be substituted independently of one another by in         each case one or two identical or different fluorine atoms or         hydroxy, C₁₋₅-alkyloxy, C₁₋₅-alkylcarbonyloxy,         C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl, amino,         C₁₋₅-alkylamino, di-(C₁₋₅-alkyl)-amino, C₁₋₅-alkylcarbonylamino         or C₁₋₅-alkylsulphonylamino groups,     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound, are replaced by a heteroatom             from the group oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a nitrile     group, a C₁₋₃-alkyl group, or a C₁₋₃-alkoxy group, while the     hydrogen atoms of the C₁₋₃-alkyl group or C₁₋₃-alkoxy group may be     wholly or partly replaced by fluorine atoms, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₅-alkyl, C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or     C₁₋₅-alkylsulphonyl group,     while, unless otherwise stated, by the term “heteroaryl group”     mentioned hereinbefore in the definitions is meant a monocyclic 5-     or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while unless otherwise stated the alkyl, alkenyl, alkynyl and         alkoxy groups contained in the foregoing definitions which have         more than two carbon atoms may be straight-chain or branched and         the alkyl groups in the previously mentioned dialkylated groups,         for example the dialkylamino groups, may be identical or         different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions may be wholly or partly replaced by         fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 3rd embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, wherein     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted in each case by one or two C₁₋₃-alkyl groups         optionally substituted by a hydroxy, C₁₋₃-alkoxy, amino,         C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered         cycloalkyleneimino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino or C₁₋₅-alkyloxycarbonylamino groups or         an aminocarbonyl, C₁₋₃-alkylaminocarbonyl or         di-(C₁₋₃-alkyl)-aminocarbonyl group and one or two methylene         groups of the cycloalkyleneimino moiety not adjacent to the         imino group may be substituted by one or two fluorine atoms or a         hydroxy, C₁₋₃-alkoxy, amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen atom or by         a —NR^(8c)— group and additionally a methylene group adjacent to         an above-mentioned —NR^(8c)— group may be replaced by a carbonyl         group, -   R¹ denotes a fluorine, chlorine, bromine or iodine atom, a     C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the     C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly     replaced by fluorine atoms, -   R² denotes a hydrogen or halogenatom or a methyl group, -   R³ denotes a hydrogen atom or a methyl group, -   R⁴ denotes a C₂₋₄-alkenyl or C₂₋₄-alkynyl group,     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             nitrile, hydroxy, a C₁₋₃-alkyloxy group,         -   while the hydrogen atoms of the C₁₋₃-alkyloxy group may             optionally be wholly or partly replaced by fluorine atoms, a             benzyloxy, C₁₋₃-alkylcarbonyloxy,             C₁₋₃-alkyloxycarbonyl-C₁₋₃-alkyloxy, C₁₋₃-alkyloxycarbonyl,             aminocarbonyl, C₁₋₃-alkylaminocarbonyl,             di-(C₁₋₃-alkyl)-aminocarbonyl,             C₃₋₆-cycloalkyleneiminocarbonyl, amino, C₁₋₃-alkylamino,             di-(C₁₋₃-alkyl)-amino, C₁₋₃-alkylcarbonylamino or             C₁₋₃-alkylsulphonylamino group,     -   a phenyl, heteroaryl, phenyl-C₁₋₂-alkyl or heteroaryl-C₁₋₂-alkyl         group,         -   where the heteroaryl group is selected from the group             consisting of pyrrolyl, oxazolyl, imidazolyl, furanyl,             thiophenyl, 1,2,4-triazolyl, 1,2,3-triazolyl, tetrazolyl,             pyridinyl, pyrimidinyl and pyrazinyl, and may optionally be             mono- to disubstituted in the heteroaryl moiety by identical             or different substituents selected from the group consisting             of halogen atoms, C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy, mono-,             di- and trifluoromethoxy groups, -   R⁵ denotes a hydrogen atom, a C₂₋₄-alkenyl or C₂₋₄-alkynyl group,     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₃-alkyloxy group, while the hydrogen atoms of the             C₁₋₃-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl group may         be replaced by an oxygen atom or a —N(R^(8c))— group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b)),         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while one or two of the carbon atoms of a C₃₋₈-cycloalkyl group         may optionally be substituted independently of one another by in         each case one or two identical or different fluorine atoms or         C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy, amino, C₁₋₃-alkylamino,         di-(C₁₋₃-alkyl)-amino or C₁₋₃-alkylcarbonylamino groups,     -   while one or two of the carbon atoms of a C₃₋₈-cycloalkenyl         group may optionally be substituted independently of one another         by one or two C₁₋₃-alkyl groups,     -   and one or two of the carbon atoms of a C₄₋₈-cycloalkenyl group         which are not bound to another carbon atom by a double bond, may         optionally be substituted independently of one another by one or         two fluorine atoms or hydroxy, C₁₋₃-alkyloxy,         di-(C₁₋₃-alkyl)-amino groups,     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound, are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a methyl     group, or a methoxy group, while the hydrogen atoms of the methyl     group or methoxy group may be wholly or partly replaced by fluorine     atoms, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₃-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₃-alkyl, C₁₋₃-alkylcarbonyl, C₁₋₄-alkyloxycarbonyl or     C₁₋₃-alkylsulphonyl group,     while, unless otherwise stated, by the term “heteroaryl group”     mentioned hereinbefore in the definitions is meant a monocyclic 5-     or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions, which have more than two         carbon atoms, unless otherwise stated, may be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions may be wholly or partly replaced by         fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 4th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted in each case by one or two C₁₋₃-alkyl groups         optionally substituted by a hydroxy, C₁₋₃-alkoxy, amino,         C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered         cycloalkyleneimino, C₁₋₅-alkylcarbonylamino,         C₁₋₅-alkylsulphonylamino or C₁₋₅-alkyloxycarbonylamino groups or         an aminocarbonyl, C₁₋₃-alkylaminocarbonyl or         di-(C₁₋₃-alkyl)-aminocarbonyl group and one or two methylene         groups of the cycloalkyleneimino moiety not adjacent to the         imino group may be substituted by one or two fluorine atoms or a         hydroxy, C₁₋₃-alkoxy, amino, C₁₋₃-alkylamino or         di-(C₁₋₃-alkyl)-amino group and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen atom or by         a —NR^(8c)— group and additionally a methylene group adjacent to         an above-mentioned —NR^(8c)— group may be replaced by a carbonyl         group, -   R¹ denotes a fluorine, chlorine, bromine atom, a methyl,     trifluoromethyl or methoxy group, -   R² denotes a hydrogen or fluorine atom, -   R³ denotes a hydrogen atom, -   R⁴ denotes a straight-chain or branched C₁₋₄-alkyl group,     -   while the hydrogen atoms of the straight-chain or branched         C₁₋₄-alkyl group may optionally be wholly or partly replaced by         fluorine atoms, and may optionally be substituted by a hydroxy,         a C₁₋₃-alkyloxy group, while the hydrogen atoms of the         C₁₋₃-alkyloxy group may optionally be wholly or partly replaced         by fluorine atoms, a benzyloxy, C₁₋₃-alkylcarbonyloxy, amino,         C₁₋₃-alkylamino or di-(C₁₋₃-alkyl)-amino group,     -   a phenyl, heteroaryl, phenyl-C₁₋₂-alkyl or heteroaryl-C₁₋₂-alkyl         group,         -   while the heteroaryl group is selected from the group             consisting of pyrrolyl, oxazolyl, imidazolyl, furanyl,             thiophenyl, 1,2,3-triazolyl, 1,2,4-triazolyl, tetrazolyl,             pyridinyl, pyrimidinyl and pyrazinyl, and may optionally be             mono- to disubstituted in the heteroaryl moiety by identical             or different substituents selected from the group consisting             of halogen atoms, C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy, mono-,             di- and trifluoromethoxy groups, -   R⁵ denotes a hydrogen atom or     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₃-alkyloxy group, while the hydrogen atoms of the             C₁₋₃-alkyloxy group may be wholly or partly replaced by             fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl group may         be replaced by an oxygen atom or a —N(R^(8c))— group,     -   while one or two carbon atoms of a C₃₋₈-cycloalkyl group may         optionally be substituted independently of one another by in         each case one or two C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy or         di-(C₁₋₃-alkyl)-amino groups,     -   with the proviso that a C₃₋₈-cycloalkyl group of this kind         formed from R⁴ and R⁵ together,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from oxygen and nitrogen, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from oxygen and             nitrogen is bound directly to the cyclic group, is separated             from another heteroatom selected from oxygen and nitrogen by             precisely one, optionally substituted, methylene group,             and/or         -   wherein two oxygen atoms are directly joined together,     -   is excluded, -   R⁶ denotes a chlorine or bromine atom, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₃-alkyl, C₁₋₃-alkylcarbonyl, or C₁₋₄-alkyloxycarbonyl     group,     while, unless otherwise stated, by the term “heteroaryl group”     mentioned hereinbefore in the definitions is meant a monocyclic 5-     or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions, which have more than two         carbon atoms, unless otherwise stated, may be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions may be wholly or partly replaced by         fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 5th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 1, 2, 3 and 4 wherein R⁴ and R⁵ do not represent hydrogen.

A 6th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 1, 2, 3, 4 and 5, wherein the group R⁶ denotes a bromine atom.

A 7th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 1, 2, 3, 4, 5 and 6, wherein R⁴ and R⁵ do not represent hydrogen and R⁶ denotes a bromine atom.

An 8th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted independently of one another by in each case one         or two C₁₋₄-alkyl groups optionally substituted by a group         R^(7a), R^(7b) or R^(7c) or by groups R^(7b) or R^(7c) and/or         one or two methylene groups of the cycloalkyleneimino moiety not         adjacent to the imino group may be substituted by one or two         fluorine atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl group or a —NR^(8c)—         group and additionally a methylene group adjacent to an         above-mentioned —NR^(8c)— group may be replaced by a carbonyl or         sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group, where a             methylene group has been replaced by an oxygen or sulphur             atom or an —NR^(8c)— group, the adjacent methylene groups             may not be substituted by a substituent from the group             R^(7a),     -   or     -   a 5- to 7-membered cycloalkenyleneimino group optionally         substituted by one or two C₁₋₄-alkyl groups optionally         substituted by a group R^(7a), R^(7b) or R^(7c), or a group         R^(7b) or R^(7c) and/or in the methylene groups of the         cycloalkenyleneimino moiety which are not adjacent to the imino         group, substituted by one or two fluorine atoms or a group         R^(7a), while the ethenylene group is not directly bound to a         nitrogen or oxygen atom and may be fused to a 5- or 6-membered         heteroaryl group, -   R¹ denotes a hydrogen or halogen atom, a C₁₋₃-alkyl or C₁₋₃-alkoxy     group, while the hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy     group may optionally be wholly or partly replaced by fluorine atoms,     a C₂₋₃-alkenyl, C₂₋₃-alkynyl, nitrile, nitro or amino group, -   R² denotes a hydrogen or halogen atom or a C₁₋₃-alkyl group, -   R³ denotes a hydrogen atom or a C₁₋₃-alkyl group, -   R⁴ and R⁵ in each case independently of one another denote     -   a hydrogen atom, a C₂₋₆-alkenyl or C₂₋₄-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₃₋₅-cycloalkyl group, a group R^(7a) or R^(7b), a             C₁₋₄-alkyloxy group which is substituted by a group R^(7b),             a mercapto, C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl group,     -   a group R^(7b),     -   a group R^(7c) or a C₁₋₅-alkyl group substituted by R^(7c),     -   a 3- to 7-membered cycloalkyl, cycloalkyl-C₁₋₅-alkyl or         cycloalkyleneimino-C₁₋₃-alkyl group,         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety a methylene group may optionally be replaced by a             —N(R^(8c))— group, an oxygen or sulphur atom or a —S(O) or             —S(O)₂ group, or         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety two adjacent methylene groups may together optionally             be replaced by a —C(O)N(R^(8b))— or —S(O)₂N(R^(8b))— group,             or         -   wherein in 6- to 7-membered cyclic groups in the cyclic             moiety three adjacent methylene groups may together             optionally be replaced by a substituted —OC(O)N(R^(8b))— or             —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,         -   while a 3- to 7-membered cycloalkyl, cycloalkyleneimino,             cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group             as hereinbefore defined may each be substituted at one or             two —CH₂— groups by one or two groups R^(8a),         -   with the proviso that a 3- to 7-membered cycloalkyl,             cycloalkyleneimino, cycloalkyl-C₁₋₅-alkyl or             cycloalkyleneimino-C₁₋₃-alkyl group as hereinbefore defined             wherein two heteroatoms from the group oxygen and nitrogen             are separated from one another by precisely one optionally             substituted —CH₂— group, is excluded,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while a C₃₋₈-cycloalkyl or C₄₋₈-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl or         C₅₋₈-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))—, or a         carbonyl, sulphinyl or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))—, —C(O)O— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while 1 to 3 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally be         substituted independently of one another in each case by one or         two fluorine atoms or one or two identical or different         C₁₋₅-alkyl groups or groups R^(7a) or R^(7b) or         carboxy-C₁₋₅-alkyl, C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl,         C₁₋₅-alkylsulphanyl or C₁₋₅-alkylsulphonyl groups,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally be substituted independently of one another in each         case by a C₁₋₅-alkyl group or a group R^(7b),     -   and 1 to 2 carbon atoms of a C₄₋₈-cycloalkenyl group which are         not bound to another carbon atom by a double bond, may         optionally be substituted independently of one another by one or         two fluorine atoms or a group R^(7a),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a     nitrile group, a C₁₋₃-alkyl group, or a C₁₋₃-alkoxy group, while the     hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally     be wholly or partly replaced by fluorine atoms, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms, allyloxy,     benzyloxy, propargyloxy, C₁₋₄-alkylcarbonyloxy,     C₁₋₄-alkyloxycarbonyloxy, amino, C₁₋₃-alkylamino,     C₃₋₆-cycloalkylamino, N—(C₁₋₃-alkyl)-N—(C₃₋₆-cycloalkyl)-amino,     arylamino, heteroarylamino, di-(C₁₋₃-alkyl)-amino,     N—C₁₋₃-alkyl-N—(C₃₋₆-cycloalkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₅-alkylsulphonylamino,     N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino,     aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a     di-(C₁₋₃-alkyl)-aminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a carboxy,     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl,     aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a hydroxyl, C₁₋₅-alkyl, C₃₋₅-cycloalkyl, C₁₋₅-alkoxy, formyl,     C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl,     aryl or heteroaryl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is preferably meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atom or a group R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom or a group R^(8a) may be fused to the         above-mentioned monocyclic aryl groups via two adjacent carbon         atoms,         while, unless otherwise stated, by the term “heteroaryl group”         mentioned hereinbefore in the definitions is meant a monocyclic         5- or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an optionally by a C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group         substituted imino group and two or three nitrogen atoms,     -   and the above-mentioned monocyclic heteroaryl groups may be         substituted in the carbon skeleton by one or two groups R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions, which have more than two         carbon atoms, unless otherwise stated, may be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

Examples of monocyclic heteroaryl groups are the pyridyl, N-oxy-pyridyl, pyrazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, [1,2,3]triazinyl, [1,3,5]triazinyl, [1,2,4]triazinyl, pyrrolyl, imidazolyl, [1,2,4]triazolyl, [1,2,3]triazolyl, tetrazolyl, furanyl, isoxazolyl, oxazolyl, [1,2,3]oxadiazolyl, [1,2,4]oxadiazolyl, furazanyl, thiophenyl, thiazolyl, isothiazolyl, [1,2,3]thiadiazolyl, [1,2,4]thiadiazolyl or [1,2,5]thiadiazolyl group.

Examples of bicyclic heteroaryl groups are the benzimidazolyl, benzofuranyl, benzo[c]furanyl, benzothiophenyl, benzo[c]thiophenyl, benzothiazolyl, benzo[c]-isothiazolyl, benzo[d]isothiazolyl, benzooxazolyl, benzo[c]isoxazolyl, benzo[d]-isoxazolyl, benzo[1,2,5]oxadiazolyl, benzo[1,2,5]thiadiazolyl, benzo[1,2,3]thia-diazolyl, benzo[d][1,2,3]triazinyl, benzo[1,2,4]triazinyl, benzotriazolyl, cinnolinyl, quinolinyl, N-oxy-quinolinyl, isoquinolinyl, quinazolinyl, N-oxy-quinazolinyl, quinoxalinyl, phthalazinyl, indolyl, isoindolyl or 1-oxa-2,3-diaza-indenyl group.

Examples of the C₁₋₆-alkyl groups mentioned hereinbefore in the definitions are the methyl, ethyl, 1-propyl, 2-propyl, n-butyl, sec-butyl, tert-butyl, 1-pentyl, 2-pentyl, 3-pentyl, neo-pentyl, 3-methyl-2-butyl, 1-hexyl, 2-hexyl, 3-hexyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 3-methyl-3-pentyl, 2-methyl-3-pentyl, 2,2-dimethyl-3-butyl or 2,3-dimethyl-2-butyl group.

Examples of the C₁₋₅-alkyloxy groups or C₁₋₅-alkoxy groups mentioned hereinbefore in the definitions are the methyloxy, ethyloxy, 1-propyloxy, 2-propyloxy, n-butyloxy, sec-butyloxy, tert-butyloxy, 1-pentyloxy, 2-pentyloxy, 3-pentyloxy or neo-pentyloxy group.

Examples of the C₂₋₆-alkenyl groups mentioned hereinbefore in the definitions are the ethenyl, 1-propen-1-yl, 2-propen-1-yl, 1-buten-1-yl, 2-buten-1-yl, 3-buten-1-yl, 1-penten-1-yl, 2-penten-1-yl, 3-penten-1-yl, 4-penten-1-yl, 1-hexen-1-yl, 2-hexen-1-yl, 3-hexen-1-yl, 4-hexen-1-yl, 5-hexen-1-yl, but-1-en-2-yl, but-2-en-2-yl, but-1-en-3-yl, 2-methyl-prop-2-en-1-yl, pent-1-en-2-yl, pent-2-en-2-yl, pent-3-en-2-yl, pent-4-en-2-yl, pent-1-en-3-yl, pent-2-en-3-yl, 2-methyl-but-1-en-1-yl, 2-methyl-but-2-en-1-yl, 2-methyl-but-3-en-1-yl, 2-ethyl-prop-2-en-1-yl, hex-1-en-2-yl, hex-2-en-2-yl, hex-3-en-2-yl, hex-4-en-2-yl, hex-5-en-2-yl, hex-1-en-3-yl, hex-2-en-3-yl, hex-3-en-3-yl, hex-4-en-3-yl, hex-5-en-3-yl, hex-1-en-4-yl, hex-2-en-4-yl, hex-3-en-4-yl, hex-4-en-4-yl, hex-5-en-4-yl, 4-methyl-pent-1-en-3-yl, 3-methyl-pent-1-en-3-yl, 2-methyl-pent-1-en-3-yl, 2,3-dimethyl-but-1-en-3-yl, 3,3-dimethyl-but-1-en-2-yl or 2-ethyl-but-1-en-3-yl group,

Examples of the C₂₋₆-alkynyl groups mentioned hereinbefore in the definitions are die ethynyl, 1-propynyl, 2-propynyl, 1-butyn-1-yl, 1-butyn-3-yl, 2-butyn-1-yl, 3-butyn-1-yl, 1-pentyn-1-yl, 1-pentyn-3-yl, 1-pentyn-4-yl, 2-pentyn-1-yl, 2-pentyn-3-yl, 3-pentyn-1-yl, 4-pentyn-1-yl, 2-methyl-1-butyn-4-yl, 3-methyl-1-butyn-1-yl, 3-methyl-1-butyn-3-yl, 1-hexyn-1-yl, 2-hexyn-1-yl, 3-hexyn-1-yl, 4-hexyn-1-yl, 5-hexyn-1-yl, 1-hexyn-3-yl, 1-hexyn-4-yl, 1-hexyn-5-yl, 2-hexyn-4-yl, 2-hexyn-5-yl, 3-hexyn-5-yl, 3-methyl-1-pentyn-3-yl, 4-methyl-1-pentyn-3-yl, 3-methyl-1-pentyn-4-yl, 4-methyl-1-pentyn-4-yl, 4-methyl-2-pentyn-4-yl, 4-methyl-2-pentyn-1-yl, 2,2-dimethyl-3-butyn-1-yl or 2-ethyl-3-butyn-1-yl group.

By a group which may be converted in vivo into a carboxy group is meant for example a carboxy group esterified with an alcohol wherein the alcoholic moiety preferably denotes a C₁₋₆-alkanol, a phenyl-C₁₋₃-alkanol, a C₃₋₉-cycloalkanol, a C₅₋₇-cycloalkenol, a C₃₋₅-alkenol, a phenyl-C₃₋₅-alkenol, a C₃₋₅-alkynol or phenyl-C₃₋₅-alkynol, with the proviso that no bond to the oxygen atom starts from a carbon atom which carries a double or triple bond, a C₃₋₈-cycloalkyl-C₁₋₃-alkanol or an alcohol of formula R⁹—CO—O—(R¹⁰CR¹¹)—OH, wherein

-   -   R⁹ denotes a C₁₋₈-alkyl, C₅₋₇-cycloalkyl, phenyl or         phenyl-C₁₋₃-alkyl group,     -   R¹⁰ denotes a hydrogen atom, a C₁₋₃-alkyl, C₅₋₇-cycloalkyl or         phenyl group and     -   R¹¹ denotes a hydrogen atom or a C₁₋₃-alkyl group.

Preferred groups which may be cleaved from a carboxy group in vivo include a C₁₋₆-alkoxy group such as the methoxy, ethoxy, n-propyloxy, isopropyloxy, n-butyloxy, n-pentyloxy, n-hexyloxy or cyclohexyloxy group or a phenyl-C₁₋₃-alkoxy group such as the benzyloxy group.

By a group which may be converted in vivo into a hydroxyl group is meant for example a hydroxyl group esterified with a carboxylic acid wherein the carboxylic acid moiety is preferably a C₁₋₇-alkanoic acid, a phenyl-C₁₋₃-alkanoic acid, a C₃₋₉-cycloalkylcarboxylic acid, a C₅₋₇-cycloalkenecarboxylic acid, a C₃₋₇-alkenoic acid, a phenyl-C₃₋₅-alkenoic acid, a C₃₋₇-alkynoic acid or phenyl-C₃₋₅-alkynoic acid, while individual methylene groups of the carboxylic acid group may be replaced by oxygen atoms, with the proviso that no bond to the oxygen atom starts from a carbon atom which carries a double or triple bond.

Examples of preferred groups which may be cleaved in vivo from a hydroxyl group include a C₁₋₇-acyl group such as the formyl, acetyl, n-propionyl, isopropionyl, n-propanoyl, n-butanoyl, n-pentanoyl, n-hexanoyl or cyclohexylcarbonyl group or a benzoyl group as well as also a methoxyacetyl, 1-methoxypropionyl, 2-methoxypropionyl or 2-methoxy-ethoxyacetyl group.

The compounds of general formula I, wherein A, R⁴ and/or R⁵ contains a group which may be converted in vivo into a carboxy or hydroxyl group are prodrugs for those compounds of general formula I wherein A, R⁴ and/or R⁵ contains a carboxy or hydroxyl group.

A 9th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, where     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted independently of one another by in each case one         or two C₁₋₄-alkyl groups optionally substituted by a group         R^(7a), R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one         or two methylene groups of the cycloalkyleneimino moiety not         adjacent to the imino group may be substituted by one or two         fluorine atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl group or a —NR^(8c)—         group and additionally a methylene group adjacent to an         above-mentioned —NR^(8c)— group may be replaced by a carbonyl or         sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group optionally     substituted by one or two C₁₋₄-alkyl groups optionally substituted     by a group R^(7a), R^(7b) or R^(7c), or a group R^(7b) or R^(7c)     and/or in the methylene groups of the cycloalkyleneimino moiety not     adjacent to the imino group by one or two fluorine atoms or a group     R^(7a), while the ethenylene group is not bound directly to a     nitrogen or oxygen atom and may be fused to a 5- or 6-membered     heteroaryl group, -   R¹ denotes a hydrogen or fluorine, chlorine, bromine or iodine atom,     a C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the     C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly     replaced by fluorine atoms, a nitrile, nitro or amino group, -   R² denotes a hydrogen or halogen atom or a methyl group, -   R³ denotes a hydrogen atom or a C₁₋₃-alkyl group, -   R⁴ and R⁵ in each case independently of one another denote     -   a hydrogen atom, a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₃₋₅-cycloalkyl group, a group R^(7a) or R^(7b), a             C₁₋₄-alkyloxy group which is substituted by a group R^(7b),             a mercapto, C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl group,     -   a group R^(7b),     -   a group R^(7c) or a C₁₋₅-alkyl group substituted by R^(7c),     -   a 3- to 7-membered cycloalkyl, cycloalkyl-C₁₋₅-alkyl or         cycloalkyleneimino-C₁₋₃-alkyl group,         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety a methylene group may optionally be replaced by a             —N(R^(8c))— group, an oxygen or sulphur atom or a —S(O) or             —S(O)₂ group, or         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety two adjacent methylene groups may together optionally             be replaced by a —C(O)N(R^(8b))— or —S(O)₂N(R^(8b))— group,             or         -   wherein in 6- to 7-membered cyclic groups in the cyclic             moiety three adjacent methylene groups may together             optionally be replaced by a substituted —OC(O)N(R^(8b))— or             —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,         -   while a 3- to 7-membered cycloalkyl, cycloalkyleneimino,             cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group             as hereinbefore defined may each be substituted at one or             two —CH₂— groups by one or two groups R^(8a),         -   with the proviso that a 3- to 7-membered cycloalkyl,             cycloalkyleneimino, cycloalkyl-C₁₋₅-alkyl or             cycloalkyleneimino-C₁₋₃-alkyl group as hereinbefore defined             wherein two heteroatoms from the group oxygen and nitrogen             are separated from one another by precisely one optionally             substituted —CH₂— group, is excluded,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while a C₃₋₈-cycloalkyl or C₄₋₈-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl or         C₅₋₈-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))—, or a         carbonyl, sulphinyl or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))—, —C(O)O— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while 1 to 3 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally be         substituted independently of one another by in each case one or         two fluorine atoms or one or two identical or different         C₁₋₅-alkyl groups or groups R^(7a) or R^(7b) or         carboxy-C₁₋₅-alkyl, C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl,         C₁₋₅-alkylsulphanyl or C₁₋₅-alkylsulphonyl groups,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally be substituted independently of one another by in         each case a C₁₋₅-alkyl groups or a group R^(7b),     -   and 1 to 2 carbon atoms of a C₄₋₈-cycloalkenyl group which are         not bound to another carbon atom by a double bond may optionally         be substituted independently of one another by one or two         fluorine atoms or a group R^(7a),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a nitrile     group, a C₁₋₃-alkyl group, or a C₁₋₃-alkoxy group, while the     hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally     be wholly or partly replaced by fluorine atoms, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms, allyloxy,     benzyloxy, propargyloxy, C₁₋₄-alkylcarbonyloxy,     C₁₋₄-alkyloxycarbonyloxy, amino, C₁₋₃-alkylamino,     C₃₋₆-cycloalkylamino, N—(C₁₋₃-alkyl)-N—(C₃₋₆-cycloalkyl)-amino,     arylamino, heteroarylamino, di-(C₁₋₃-alkyl)-amino,     N—C₁₋₃-alkyl-N—(C₃₋₆-cycloalkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₅-alkylsulphonylamino,     N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino,     aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a     di-(C₁₋₃-alkyl)-aminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a carboxy,     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl,     aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a hydroxyl, C₁₋₅-alkyl, C₃₋₅-cycloalkyl, C₁₋₅-alkoxy, formyl,     C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl,     aryl or heteroaryl group, while, unless otherwise stated, by the     term “aryl group” mentioned hereinbefore in the definitions is     preferably meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atoms or a group R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom or a group R^(8a) may be fused to the         above-mentioned monocyclic aryl groups via two adjacent carbon         atoms,         while, unless otherwise stated, by the term “heteroaryl group”         mentioned hereinbefore in the definitions is meant a monocyclic         5- or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and the above-mentioned monocyclic heteroaryl groups in the         carbon skeleton may be substituted by one or two groups R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions which have more than two         carbon atoms may, unless otherwise stated, be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 10th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         be substituted independently of one another by in each case one         or two C₁₋₄-alkyl groups optionally substituted by a group         R^(7a), R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one         or two methylene groups of the cycloalkyleneimino moiety not         adjacent to the imino group may be substituted by one or two         fluorine atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl group or a —NR^(8c)—         group and additionally a methylene group adjacent to an         above-mentioned —NR^(8c)— group may be replaced by a carbonyl or         sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group optionally     substituted by one or two C₁₋₄-alkyl groups optionally substituted     by a group R^(7a), R^(7b) or R^(7c) or a group R^(7b) or R^(7c)     and/or in the methylene groups of the cycloalkyleneimino moiety not     adjacent to the imino group by one or two fluorine atoms or a group     R^(7a), while the ethenylene group is not bound directly to a     nitrogen or oxygen atom and may be fused to a 5- or 6-membered     heteroaryl group, -   R¹ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a     C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the     C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly     replaced by fluorine atoms, -   R² denotes a hydrogen or halogen atom or a methyl group, -   R³ denotes a hydrogen atom or a methyl group, -   R⁴ denotes a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₃₋₅-cycloalkyl group, a group R^(7a) or R^(7b), a             C₁₋₄-alkyloxy group which is substituted by a group R^(7b),             a mercapto, C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl group,     -   a group R^(7b),     -   a group R^(7c) or a C₁₋₅-alkyl group substituted by R^(7c)     -   a 3- to 7-membered cycloalkyl, cycloalkyl-C₁₋₅-alkyl or         cycloalkyleneimino-C₁₋₃-alkyl group,         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety a methylene group may optionally be replaced by a             —N(R^(8c))— group, an oxygen or sulphur atom or a —S(O) or             —S(O)₂ group, or         -   wherein in 4- to 7-membered cyclic groups in the cyclic             moiety two adjacent methylene groups may together optionally             be replaced by a —C(O)N(R^(8b))— or —S(O)₂N(R^(8b))— group,             or         -   wherein in 6- to 7-membered cyclic groups in the cyclic             moiety three adjacent methylene groups may together             optionally be replaced by a substituted —OC(O)N(R^(8b))— or             —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,         -   while a 3- to 7-membered cycloalkyl, cycloalkyleneimino,             cycloalkyl-C₁₋₅-alkyl or cycloalkyleneimino-C₁₋₃-alkyl group             as hereinbefore defined may each be substituted at one or             two —CH₂— groups by one or two groups R^(8a),         -   with the proviso that a 3- to 7-membered cycloalkyl,             cycloalkyleneimino, cycloalkyl-C₁₋₅-alkyl or             cycloalkyleneimino-C₁₋₃-alkyl group as hereinbefore defined             wherein two heteroatoms from the group oxygen and nitrogen             are separated from one another by precisely one optionally             substituted —CH₂— group, is excluded, -   R⁵ denotes a hydrogen atom, a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₅-alkyloxy group, while the hydrogen atoms of the             C₁₋₅-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while a C₃₋₈-cycloalkyl or C₄₋₈-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl or         C₅₋₈-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))—, or a         carbonyl, sulphinyl or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))—, —C(O)O— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while 1 to 3 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally each be         substituted independently of one another by one or two fluorine         atoms or one or two identical or different C₁₋₅-alkyl groups or         groups R^(7a) or R^(7b) or carboxy-C₁₋₅-alkyl,         C₁₋₅-alkyloxycarbonyl-C₁₋₅-alkyl, C₁₋₅-alkylsulphanyl or         C₁₋₅-alkylsulphonyl groups,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally each be substituted independently of one another by a         C₁₋₅-alkyl groups or a group R^(7b),     -   and 1 to 2 carbon atoms of a C₄₋₈-cycloalkenyl group which are         not bound to another carbon atom by a double bond may optionally         be substituted independently of one another by one or two         fluorine atoms or a group R^(7a),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a nitrile     group, a C₁₋₃-alkyl group, or a C₁₋₃-alkoxy group, while the     hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally     be wholly or partly replaced by fluorine atoms, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms, allyloxy,     benzyloxy, propargyloxy, C₁₋₄-alkylcarbonyloxy,     C₁₋₄-alkyloxycarbonyloxy, amino, C₁₋₃-alkylamino,     C₃₋₆-cycloalkylamino, N—(C₁₋₃-alkyl)-N—(C₃₋₆-cycloalkyl)-amino,     arylamino, heteroarylamino, di-(C₁₋₃-alkyl)-amino,     N—C₁₋₃-alkyl-N—(C₃₋₆-cycloalkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₅-alkylsulphonylamino,     N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino,     aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a     di-(C₁₋₃-alkyl)-aminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a carboxy,     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl,     aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a hydroxyl, C₁₋₅-alkyl, C₃₋₅-cycloalkyl, C₁₋₅-alkoxy, formyl,     C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl,     aryl or heteroaryl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is preferably meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atom or a group R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom or a group R^(8a) may be fused to the         above-mentioned monocyclic aryl groups via two adjacent carbon         atoms,         while, unless otherwise stated, by the term “heteroaryl group”         mentioned hereinbefore in the definitions is meant a monocyclic         5- or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and the above-mentioned monocyclic heteroaryl groups in the         carbon skeleton may be substituted by one or two groups R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions, which have more than two         carbon atoms, may, unless otherwise stated, be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

An 11th embodiment of the present invention comprises those compounds of general formula I wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         each be substituted independently of one another by one or two         C₁₋₄-alkyl groups optionally substituted by a group R^(7a),         R^(7b) or R^(7c), or groups R^(7b) or R^(7c) and/or one or two         methylene groups of the cycloalkyleneimino moiety not adjacent         to the imino group may be substituted by one or two fluorine         atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl group or a R^(8c)         group and additionally a methylene group adjacent to an         above-mentioned —NR^(8c)— group may be replaced by a carbonyl or         sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group optionally     substituted by one or two C₁₋₄-alkyl groups optionally substituted     by a group R^(7a), R^(7b) or R^(7c), or a group R^(7b) or R^(7c)     and/or in the methylene groups of the cycloalkyleneimino moiety not     adjacent to the imino group may be substituted by one or two     fluorine atoms or a group R^(7a), while the ethenylene group is not     bound directly to a nitrogen or oxygen atom and may be fused to a 5-     or 6-membered heteroaryl group, -   R¹ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a     C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the     C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly     replaced by fluorine atoms, -   R² denotes a hydrogen or halogen atom or a methyl group, -   R³ denotes a hydrogen atom, -   R⁴ denotes a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₃₋₅-cycloalkyl group, a group R^(7d) or R^(7e), a             C₁₋₄-alkyloxy group which is substituted by a group R^(7e),             a C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl group,     -   a group R^(7c) or a C₁₋₅-alkyl group substituted by R^(7c), -   R⁵ denotes a hydrogen atom, a C₂₋₄-alkenyl or C₂₋₄-alkynyl group,     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₄-alkyloxy group, while the hydrogen atoms of the             C₁₋₄-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while a C₃₋₈-cycloalkyl or C₄₋₈-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl or         C₅₋₈-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))—, or a         carbonyl, sulphinyl or sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))—, —C(O)O— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while 1 to 3 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally each be         substituted independently of one another by one or two fluorine         atoms or one or two identical or different C₁₋₅-alkyl groups or         groups R^(7d) or R^(7e) or C₁₋₅-alkylsulphanyl or         C₁₋₅-alkylsulphonyl groups,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkenyl group may         optionally each be substituted independently of one another by a         C₁₋₅-alkyl groups or a group R^(7e),     -   and 1 to 2 carbon atoms of a C₄₋₈-cycloalkenyl group which are         not bound to another carbon atom by a double bond may optionally         be substituted independently of one another by one or two         fluorine atoms or a group R^(7d),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a nitrile,     methyl or methoxy group, while the hydrogen atoms of the methyl or     methoxy group may optionally be wholly or partly replaced by     fluorine atoms, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms, allyloxy,     benzyloxy, propargyloxy, C₁₋₄-alkylcarbonyloxy,     C₁₋₄-alkyloxycarbonyloxy, amino, C₁₋₃-alkylamino,     C₃₋₆-cycloalkylamino, N—(C₁₋₃-alkyl)-N—(C₃₋₆-cycloalkyl)-amino,     arylamino, heteroarylamino, di-(C₁₋₃-alkyl)-amino,     N—C₁₋₃-alkyl-N—(C₃₋₆-cycloalkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₅-alkylsulphonylamino,     N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino,     aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a     di-(C₁₋₃-alkyl)-aminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a carboxy,     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(7d) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₁₋₅-alkylcarbonylamino or C₁₋₅-alkoxycarbonylamino group, -   R^(7e) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl,     aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a hydroxyl, C₁₋₅-alkyl, C₃₋₅-cycloalkyl, C₁₋₅-alkoxy, formyl,     C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl,     aryl or heteroaryl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is preferably meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atom or a group R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom or a group R^(8a) may be fused to the         above-mentioned monocyclic aryl groups via two adjacent carbon         atoms,         while, unless otherwise stated, by the term “heteroaryl group”         mentioned hereinbefore in the definitions is meant a monocyclic         5- or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group,         or an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group, and two or three nitrogen atoms,     -   and the above-mentioned monocyclic heteroaryl groups may be         substituted in the carbon skeleton by one or two groups R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkenyl, alkynyl and alkoxy groups contained in         the previously mentioned definitions, which have more than two         carbon atoms, unless otherwise stated, may be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 12th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         each be substituted independently of one another by one or two         C₁₋₄-alkyl groups optionally substituted by a group R^(7a),         R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one or two         methylene groups of the cycloalkyleneimino moiety not adjacent         to the imino group may be substituted by one or two fluorine         atoms or by a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a carbonyl, sulphinyl, sulphonyl group or a —NR^(8c)—         group and additionally a methylene group adjacent to an         above-mentioned —NR^(8c)— group may be replaced by a carbonyl or         sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group optionally     substituted by one or two C₁₋₄-alkyl groups optionally substituted     by a group R^(7a), R^(7b) or R^(7c), or a group R^(7b) or R^(7c)     and/or in the methylene groups of the cycloalkyleneimino moiety not     adjacent to the imino group substituted by one or two fluorine atoms     or a group R^(7a), while the ethenylene group is not bound directly     to a nitrogen or oxygen atom and may be fused to a 5- or 6-membered     heteroaryl group, -   R¹ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a     methyl or methoxy group, while the hydrogen atoms of the methyl or     methoxy group may optionally be wholly or partly replaced by     fluorine atoms, -   R² denotes a hydrogen or fluorine atom or a methyl group, -   R³ denotes a hydrogen atom, -   R⁴ denotes a C₂₋₆-alkenyl or C₂₋₆-alkynyl group,     -   a straight-chain or branched C₁₋₆-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₆-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₃₋₅-cycloalkyl group, a group R^(7d) or R^(7e), a             C₁₋₄-alkyloxy group which is substituted by a group R^(7e),             a C₁₋₅-alkylsulphanyl, C₁₋₅-alkylsulphonyl group,     -   a group R^(7c) or a C₁₋₅-alkyl group substituted by R^(7c), -   R⁵ denotes a hydrogen atom, a C₂₋₄-alkenyl or C₂₋₄-alkynyl group,     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₄-alkyloxy group, while the hydrogen atoms of the             C₁₋₄-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl group,     -   while a C₃₋₈-cycloalkyl or C₄₋₈-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₈-cycloalkyl or         C₅₋₈-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))— or         sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₈-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))—, —C(O)O— or         —S(O)₂N(R^(8b))— group, and/or     -   three directly adjacent methylene groups of a C₆₋₈-cycloalkyl         group may together be replaced by a —OC(O)N(R^(8b))—,         —N(R^(8b))C(O)N(R^(8b))— or —N(R^(8b))S(O)₂N(R^(8b))— group,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally each be         substituted independently of one another by one or two fluorine         atoms or a C₁₋₃-alkyl groups or a group R^(7d) or R^(7e),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a fluorine, chlorine, bromine or iodine atom, a methyl or     methoxy group, while the hydrogen atoms of the methyl or methoxy     group may optionally be wholly or partly replaced by fluorine atoms, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₄-alkyloxycarbonyloxy, amino,     C₁₋₃-alkylamino, C₃₋₆-cycloalkylamino,     N—(C₁₋₃-alkyl)-N—(C₃₋₆-cycloalkyl)-amino, arylamino,     heteroarylamino, di-(C₁₋₃-alkyl)-amino,     N—C₁₋₃-alkyl-N—(C₃₋₆-cycloalkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₅-alkylsulphonylamino,     N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino,     aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a     di-(C₁₋₃-alkyl)-aminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a carboxy,     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(7d) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₁₋₅-alkylcarbonylamino or C₁₋₅-alkoxycarbonylamino group, -   R^(7e) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl,     aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₅-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a hydroxyl, C₁₋₅-alkyl, C₃₋₅-cycloalkyl, C₁₋₅-alkoxy, formyl,     C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl,     aryl or heteroaryl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is preferably meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atom or a group R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom or a group R^(8a), may be fused to the         above-mentioned monocyclic aryl groups via two adjacent carbon         atoms,         while, unless otherwise stated, by the term “heteroaryl group”         mentioned hereinbefore in the definitions is meant a monocyclic         5- or 6-membered heteroaryl group, while     -   the 6-membered heteroaryl group contains one, two or three         nitrogen atoms and     -   the 5-membered heteroaryl group contains an imino group         optionally substituted by a C₁₋₃-alkyl, phenyl or         phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl, phenyl,         amino-C₂₋₃-alkyl, C₁₋₃-alkylamino-C₂₋₃-alkyl,         di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a         C₃₋₄-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or         an oxygen or sulphur atom and additionally a nitrogen atom or     -   an imino group optionally substituted by a C₁₋₃-alkyl or         phenyl-C₁₋₃-alkyl group and two or three nitrogen atoms,     -   and the above-mentioned monocyclic heteroaryl groups may be         substituted in the carbon skeleton by one or two groups R^(8a),     -   and moreover a phenyl ring optionally substituted by a fluorine,         chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy         group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or         C₃₋₆-cycloalkyleneimino group may be fused to the         above-mentioned monocyclic heteroaryl groups via two adjacent         carbon atoms     -   and the bond is effected via a nitrogen atom or a carbon atom of         the heterocyclic moiety or a fused-on phenyl ring,         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl, alkynyl and alkoxy groups contained in the         previously mentioned definitions which have more than two carbon         atoms may, unless otherwise stated, be straight-chain or         branched and the alkyl groups in the previously mentioned         dialkylated groups, for example the dialkylamino groups, may be         identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 13th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 4- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         each be substituted independently of one another by one or two         C₁₋₄-alkyl groups optionally substituted by a group R^(7a),         R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one or two         methylene groups of the cycloalkyleneimino moiety not adjacent         to the imino group may be substituted by one or two fluorine         atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom, by a sulphonyl group or a —NR^(8c)— group and additionally         a methylene group adjacent to an above-mentioned —NR^(8c)— group         may be replaced by a carbonyl or sulphonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or     -   denotes a 5- to 7-membered cycloalkenyleneimino group optionally         substituted by one or two C₁₋₄-alkyl groups optionally         substituted by a group R^(7a), R^(7b) or R^(7c), or a group         R^(7b) or R^(7c), and/or, in the methylene groups of the         cycloalkyleneimino moiety not adjacent to the imino group,         substituted by one or two fluorine atoms or a group R^(7a),         while the ethenylene group is not bound directly to a nitrogen         or oxygen atom, -   R¹ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a     methyl or methoxy group, while the hydrogen atoms of the methyl or     methoxy group may optionally be wholly or partly replaced by     fluorine atoms, -   R² denotes a hydrogen or fluorine atom, -   R³ denotes a hydrogen atom, -   R⁴ denotes a straight-chain or branched C₁₋₄-alkyl group,     -   while the hydrogen atoms of the straight-chain or branched         C₁₋₄-alkyl group may optionally be wholly or partly replaced by         fluorine atoms, and may optionally be substituted by a         C₃₋₅-cycloalkyl group, a group R^(7d) or R^(7e), a C₁₋₄-alkyloxy         group which is substituted by a group R^(7e), a         C₁₋₄-alkylsulphanyl, C₁₋₄-alkylsulphonyl group,     -   a group R^(7c) or a C₁₋₃-alkyl group substituted by R^(7c), -   R⁵ denotes a hydrogen atom,     -   a straight-chain or branched C₁₋₄-alkyl group,         -   while the hydrogen atoms of the straight-chain or branched             C₁₋₄-alkyl group may optionally be wholly or partly replaced             by fluorine atoms, and may optionally be substituted by a             C₁₋₄-alkyloxy group, while the hydrogen atoms of the             C₁₋₄-alkyloxy group may optionally be wholly or partly             replaced by fluorine atoms,     -   or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₇-cycloalkyl or C₄₋₇-cycloalkenyl group,     -   while a C₃₋₇-cycloalkyl or C₄₋₇-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₅-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₇-cycloalkyl or         C₅₋₇-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))— or         sulphonyl group, and/or     -   two directly adjacent methylene groups of a C₄₋₇-cycloalkyl         group may together be replaced by a —C(O)N(R^(8b))— or —C(O)O—         group,     -   while 1 to 2 carbon atoms of a C₃₋₈-cycloalkyl group or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group may optionally each be         substituted independently of one another by one or two fluorine         atoms or a C₁₋₃-alkyl groups or a group R^(7d) or R^(7e),     -   with the proviso that a C₃₋₈-cycloalkyl or C₃₋₈-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein two heteroatoms in the cyclic group selected from             oxygen and nitrogen are separated from one another by             precisely one optionally substituted —CH₂— group, and/or         -   wherein one or both methylene groups of the cyclic group             which are directly connected to the carbon atom to which the             groups R⁴ and R⁵ are bound are replaced by a heteroatom             selected from among oxygen, nitrogen and sulphur, and/or         -   wherein a substituent bound to the cyclic group which is             characterised in that a heteroatom selected from among the             oxygen, nitrogen, sulphur and halogen atom is bound directly             to the cyclic group, is separated from another heteroatom             selected from among oxygen, nitrogen and sulphur, with the             exception of the sulphone group, by precisely one,             optionally substituted, methylene group, and/or         -   wherein two oxygen atoms are directly joined together,             and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             or more of which corresponds to an oxygen or sulphur atom or             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a chlorine or bromine atom, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₄-alkyloxycarbonyloxy, amino,     C₁₋₃-alkylamino, phenylamino, di-(C₁₋₃-alkyl)-amino, a 4- to     7-membered cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl,     piperazin-1-yl, N—C₁₋₃-alkyl-piperidin-4-yl,     4-C₁₋₃-alkyl-piperazin-1-yl, N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₄-alkylaminocarbonylamino,     C₁₋₅-alkylsulphonylamino, N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino or     C₁₋₅-alkoxycarbonylamino group, -   R^(7b) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(7d) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₁₋₅-alkylcarbonylamino or C₁₋₅-alkoxycarbonylamino group, -   R^(7e) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     nitrile, C₁₋₃-alkylaminocarbonyl or a di-(C₁₋₃-alkyl)-aminocarbonyl     group, -   R^(8b) in each case independently of one another denotes a hydrogen     atom or a C₁₋₃-alkyl group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₃-alkyl, C₃₋₅-cycloalkyl, C₁₋₃-alkoxy, formyl,     C₁₋₃-alkylcarbonyl or C₁₋₄-alkyloxycarbonyl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atom or a group R^(8a),         while the “heteroaryl group” mentioned in the definitions given         hereinbefore is selected from the group consisting of pyrrolyl,         oxazolyl, imidazolyl, furanyl, thiophenyl, thiazolyl,         1,2,3-triazolyl, 1,2,4-triazolyl, tetrazolyl, pyridinyl,         pyrimidinyl and pyrazinyl, and may optionally be mono- to         disubstituted in the carbon skeleton by identical or different         substituents selected from the group consisting of halogen atoms         and R^(8a), while the NH groups contained in 5-membered         heteroaryl groups may be substituted by a group R^(8b),         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl and alkoxy groups contained in the definitions         given hereinbefore which have more than two carbon atoms may,         unless otherwise stated, be straight-chain or branched and the         alkyl groups in the previously mentioned dialkylated groups, for         example the dialkylamino groups, may be identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 14th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 5- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         each be substituted independently of one another by one or two         C₁₋₄-alkyl groups optionally substituted by a group R^(7a),         R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one or two         methylene groups of the cycloalkyleneimino moiety not adjacent         to the imino group may be substituted by one or two fluorine         atoms or a group R^(7a) and/or     -   a methylene group in the 3 position of a 5-membered         cycloalkyleneimino group may be replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom or a —NR^(8c)— group and additionally a methylene group         adjacent to an above-mentioned —NR^(8c)— group may be replaced         by a carbonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group optionally     substituted by one or two C₁₋₄-alkyl groups optionally substituted     by a group R^(7a), R^(7b) or R^(7c) or a group R^(7b) or R^(7c)     and/or, in the methylene groups of the cycloalkyleneimino moiety not     adjacent to the imino group, by one or two fluorine atoms or a group     R^(7a), while the ethenylene group is not bound directly to a     nitrogen or oxygen atom, -   R¹ denotes a hydrogen, fluorine, chlorine, bromine atom or a methyl     or methoxy group, while the hydrogen atoms of the methyl or methoxy     group may optionally be wholly or partly replaced by fluorine atoms, -   R² denotes a hydrogen or fluorine atom, -   R³ denotes a hydrogen atom, -   R⁴ denotes a straight-chain or branched C₁₋₃-alkyl group which may     optionally be substituted by a C₃₋₅-cycloalkyl group, a group R^(7d)     or R^(7e), a C₁₋₂-alkyloxy group, a C₁₋₂-alkylsulphanyl,     C₁₋₂-alkylsulphonyl group,     -   a group R^(7c) or a C₁₋₃-alkyl group substituted by R^(7c), -   R⁵ denotes a hydrogen atom, or a methyl group, or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₆-cycloalkyl or C₅₋₆-cycloalkenyl group,     -   while a C₃₋₆-cycloalkyl or C₅₋₆-cycloalkenyl group may be         substituted at an individual carbon atom by a C₂₋₄-alkylene         group or simultaneously at two different carbon atoms by a         C₁₋₄-alkylene group, forming a corresponding spirocyclic group         or a bridged bicyclic group,     -   while one of the methylene groups of a C₄₋₆-cycloalkyl or         C₅₋₆-cycloalkenyl group or a corresponding spirocyclic group as         described above or a corresponding bridged bicyclic group may be         replaced by an oxygen or sulphur atom or a —N(R^(8c))— or         sulphonyl group,     -   with the proviso that a C₃₋₇-cycloalkyl or C₅₋₆-cycloalkenyl         group of this kind formed from R⁴ and R⁵ together or a         corresponding spirocyclic group as described above or a         corresponding bridged bicyclic group,         -   wherein a methylene groups of the cyclic group which are             directly connected to the carbon atom to which the groups R⁴             and R⁵ are bound are replaced by a heteroatom selected from             among oxygen, nitrogen and sulphur, and/or         -   wherein a heteroatom selected from among oxygen, nitrogen             and sulphur is linked directly to a carbon atom which is             linked to another carbon atom by a double bond, and/or         -   which contains a cyclic group with three ring members, one             of which corresponds to an oxygen or sulphur atom or the             —N(R^(8c))— group,     -   is excluded, -   R⁶ denotes a chlorine or bromine atom, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, C₁₋₄-alkylcarbonyloxy, amino, C₁₋₃-alkylamino,     phenylamino, di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered     cycloalkyleneimino, morpholin-4-yl, piperidin-4-yl, piperazin-1-yl,     N—C₁₋₃-alkyl-piperidin-4-yl, 4-C₁₋₃-alkyl-piperazin-1-yl,     N—C₁₋₃-alkylcarbonyl-piperidin-4-yl,     4-C₁₋₃-alkylcarbonyl-piperazin-1-yl, C₁₋₅-alkylcarbonylamino,     C₃₋₆-cycloalkylcarbonylamino, C₁₋₄-alkylaminocarbonylamino,     C₁₋₅-alkylsulphonylamino, N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino or     C₁₋₅-alkoxycarbonylamino group, -   R^(7b) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, a 4- to 7-membered     cycloalkyleneiminocarbonyl, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl, di-(C₁₋₄-alkyl)-aminosulphonyl or     C₃₋₆-cycloalkyleneiminosulphonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(7d) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may     optionally be wholly or partly replaced by fluorine atoms,     C₁₋₄-alkylcarbonyloxy, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     C₁₋₅-alkylcarbonylamino or C₁₋₅-alkoxycarbonylamino group, -   R^(7e) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl,     di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl,     C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, -   R^(8a) in each case independently of one another denotes a     C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or     partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the     hydrogen atoms may optionally be wholly or partly replaced by     fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino,     nitrile, C₁₋₃-alkylaminocarbonyl or a di-(C₁₋₃-alkyl)-aminocarbonyl     group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₃-alkyl, C₃₋₅-cycloalkyl, C₁₋₃-alkoxy, formyl,     C₁₋₃-alkylcarbonyl or C₁₋₄-alkyloxycarbonyl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is meant a phenyl group,     -   which may optionally be substituted by one or two fluorine,         chlorine or bromine atoms or a group R^(8a),         while the “heteroaryl group” mentioned in the definitions given         hereinbefore is selected from the group consisting of         imidazolyl, furanyl, oxazolyl, tetrazolyl, pyridinyl,         pyrimidinyl and pyrazinyl, while one or two carbon atoms or the         NH group contained in 5-membered heteroaryl groups may be         substituted by a group R^(8b),         while, unless otherwise stated, by the term “halogen atom”         mentioned hereinbefore in the definitions is meant an atom         selected from among fluorine, chlorine, bromine and iodine,         while the alkyl and alkoxy groups contained in the definitions         given hereinbefore which have more than two carbon atoms may,         unless otherwise stated, be straight-chain or branched and the         alkyl groups in the previously mentioned dialkylated groups, for         example the dialkylamino groups, may be identical or different,         and the hydrogen atoms of the methyl or ethyl groups contained         in the foregoing definitions, unless otherwise stated, may be         wholly or partly replaced by fluorine atoms,         the tautomers, the enantiomers, the diastereomers, the mixtures         thereof and the salts thereof.

A 15th embodiment of the present invention comprises those compounds of general formula I, wherein

-   A denotes a 5- to 7-membered cycloalkyleneimino group, while     -   one or two methylene groups of the cycloalkyleneimino moiety may         each be substituted independently of one another by one or two         C₁₋₃-alkyl groups optionally substituted by a group R^(7a),         R^(7b) or R^(7c), or groups R^(7b) or R^(7c), and/or one or two         methylene groups of the cycloalkyleneimino moiety not adjacent         to the imino group may be substituted by one or two fluorine         atoms or a group R^(7a) and/or a methylene group in the 3         position of a 5-membered cycloalkyleneimino group may be         replaced by a sulphur atom, or     -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen or sulphur         atom or a —NR^(8c)— group and additionally a methylene group         adjacent to an above-mentioned —NR^(8c)— group may be replaced         by a carbonyl group,         -   with the proviso that in a cycloalkyleneimino group wherein             a methylene group has been replaced by an oxygen or sulphur             atom or a —NR^(8c)— group, the adjacent methylene groups may             not be substituted by a substituent from the group R^(7a),     -   or -    denotes a 5- to 7-membered cycloalkenyleneimino group, while the     ethenylene group is not bound directly to a nitrogen atom, -   R¹ denotes a hydrogen, chlorine or bromine atom or a methyl group, -   R² denotes a hydrogen or fluorine atom, -   R³ denotes a hydrogen atom, -   R⁴ denotes a straight-chain or branched C₁₋₃-alkyl group which may     optionally be substituted by a group R^(7d),     -   a group R^(7c) or a C₁₋₃-alkyl group substituted by R^(7c), -   R⁵ denotes a hydrogen atom, or a methyl group, or -   R⁴ and R⁵ together with the carbon atom to which they are bound form     a C₃₋₆-cycloalkyl group,     -   while one of the methylene groups of a C₄₋₆-cycloalkyl group may         be replaced by an oxygen atom or a —N(R^(8c))— group,     -   with the proviso that a C₃₋₇-cycloalkyl group of this kind         formed from R⁴ and R⁵ together,         -   wherein a methylene groups of the cyclic group which are             directly connected to the carbon atom to which the groups R⁴             and R⁵ are bound are replaced by a heteroatom selected from             oxygen and nitrogen,     -   is excluded, -   R⁶ denotes a chlorine or bromine atom, -   R^(7a) in each case independently of one another denotes a hydroxy,     C₁₋₄-alkoxy, amino, C₁₋₃-alkylamino, phenylamino,     di-(C₁₋₃-alkyl)-amino, a 4- to 7-membered cycloalkyleneimino,     C₁₋₅-alkylsulphonylamino, or C₁₋₄-alkylaminocarbonylamino group, -   R^(7b) in each case independently of one another denotes a     C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl or     di-(C₁₋₃-alkyl)-aminocarbonyl group, -   R^(7c) in each case independently of one another denotes an aryl or     heteroaryl group, -   R^(7d) in each case independently of one another denotes a hydroxy     or C₁₋₃-alkoxy group, -   R^(8c) in each case independently of one another denotes a hydrogen     atom, a C₁₋₃-alkyl, formyl, or C₁₋₃-alkylcarbonyl group,     while, unless otherwise stated, by the term “aryl group” mentioned     hereinbefore in the definitions is meant a phenyl group,     while the “heteroaryl group” mentioned in the definitions given     hereinbefore is selected from the group consisting of imidazolyl and     pyridinyl,     while, unless otherwise stated, by the term “halogen atom” mentioned     hereinbefore in the definitions is meant an atom selected from among     fluorine, chlorine, bromine and iodine,     while the alkyl and alkoxy groups contained in the definitions given     hereinbefore which have more than two carbon atoms may, unless     otherwise stated, be straight-chain or branched and the alkyl groups     in the previously mentioned dialkylated groups, for example the     dialkylamino groups, may be identical or different,     and the hydrogen atoms of the methyl or ethyl groups contained in     the foregoing definitions, unless otherwise stated, may be wholly or     partly replaced by fluorine atoms,     the tautomers, the enantiomers, the diastereomers, the mixtures     thereof and the salts thereof.

A 16th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 8, 9, 10, 11, 12, 13, 14 or 15, wherein R⁴ and R⁵ do not represent hydrogen.

A 17th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15 or 16, wherein R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclic group which is defined in each case as in the 9th, 10th, 11th, 12th, 13th, 14th or 15th embodiment.

An 18th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16 or 17, wherein R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclic group which is defined in each case as in the 9th, 10th, 11th, 12th, 13th, 14th or 15th embodiment, while in the cyclic group or the corresponding bridged bicyclic group or the spirocyclic group according to the measures described a methylene group is replaced by an oxygen atom or a N(R^(8c)) group.

A 19th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 16, 17 or 18, wherein R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclic group, which by corresponding substitution as described in the 9th, 10th, 11th, 12th, 13th or 14th embodiment denotes a bridged bicyclic group or a spirocyclic group.

A 20th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18, wherein R⁴ and R⁵ together with the carbon atom to which they are bound denote a cyclic group

A 21st embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 16, 17, 18 or 19, wherein R⁴ and R⁵ together with the carbon atom to which they are bound denote a bridged bicyclic group

A 22nd embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 or 21, wherein

A denotes a 5- to 7-membered cycloalkyleneimino group, while

-   -   a methylene group of the cycloalkyleneimino moiety may be         substituted by a C₁₋₃-alkyl or pyridyl group optionally         substituted by a hydroxy, C₁₋₃-alkoxy, di-(C₁₋₃-alkyl)-amino, a         5- to 6-membered cycloalkyleneimino, C₁₋₃-alkylcarbonylamino or         C₁₋₃-alkylsulphonylamino group.

A 23rd embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21 or 22, wherein

A denotes a 5- to 7-membered cycloalkyleneimino group, while

-   -   a methylene group in the 4 position of a 6- or 7-membered         cycloalkyleneimino group may be replaced by an oxygen atom or by         a —NR^(8c)— group and additionally a methylene group adjacent to         an above-mentioned —NR^(8c)— group may be replaced by a carbonyl         group.

A 24th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 and 23, wherein R⁶ denotes a bromine atom.

A 25th embodiment of the present invention comprises those compounds of general formula I corresponding to the embodiments 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22 and 23, wherein R⁶ denotes a chlorine atom.

The following preferred compounds of general formula I will now be mentioned by way of example:

-   (1) 5-chloro-thiophene-2-carboxylic     acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (2) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (3) 5-chloro-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (4) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (5) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (6) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (7) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (8) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (9) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (10) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (11) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (12) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2,5-dihydropyrrol-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (13) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiazolidin-3-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (14) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-dimethylaminomethylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (15) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-fluorpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (16) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (17) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (18) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (19) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (20) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methypiperazin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (21) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methyl-1,4-diazepan-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (22) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (23) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (24) 5-bromo-thiophene-2-carboxylic     acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (25) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methylsulphanyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (26) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-butyl}-amide, -   (27) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyloxycarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (28) 5-bromo-thiophene-2-carboxylic     acid-N-{3-dimethylaminocarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (29) 5-bromo-thiophene-2-carboxylic     acid-N-{2-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (30) 5-bromo-thiophene-2-carboxylic     acid-N-{1-(thiophenyl-3-yl)-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide, -   (31) 5-bromo-thiophene-2-carboxylic     acid-N-{5-dimethylamino-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-pentyl}-amide, -   (32) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(2,2-dimethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide, -   (33) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide, -   (34) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclohexyl}-amide, -   (35) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (36) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (37) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (38) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (39) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-4-[3-trifluoromethyl-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-piperazin-4-yl}-amide, -   (40) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-4-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-piperazin-4-yl}-amide, -   (41) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methoxy-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-cycloheptyl}-amide, -   (42) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (43) 5-chloro-thiophene-2-carboxylic     acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (44) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-1-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide, -   (45) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclobut-1-yl}-amide, -   (46) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (47) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[1-methyl-1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (48) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (49) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (50) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (51) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (52) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (53) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-cyclopent-1-yl}-amide, -   (54) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (55) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (56) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (57) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (58) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (59) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (60) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (61) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (62) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (63) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (64) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (65) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (66) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (67) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (68) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (69) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (70) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (71) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{3-hydroxy-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (72) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-oxo-thiomorpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (73) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S,4R)-2-methoxycarbonyl-4-hydroxy-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (74) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3,5-dimethyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (75) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-aminocarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (76) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-methyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (77) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-methyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (78) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-{3-butyl-ureido}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (79) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{dimethylaminocarbonyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (80) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{methylaminocarbonyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (81) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methoxycarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (82) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2R)-2-aminocarbonyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (83) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-{1-butyl-sulphonylamino}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (84) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-hydroxy-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (85) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methoxycarbonyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (86) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin-3-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (87) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{4-dimethylamino-but-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (88) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2R)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (89) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiomorpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (90) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methyl-morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (91) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2R)-2-methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (92) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{2-diethylamino-eth-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (93) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-methyl-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (94) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiazolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (95) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3,6-dihydro-2H-pyridin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (96) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(azepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (97) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3,3-dimethyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (98) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-ethyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (99) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-ethoxycarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (100) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{N-ethyl-N-methyl-amino-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (101) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{3-dimethylamino-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (102) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{piperidin-1-yl-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (103) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{methoxy-carbonyl-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (104) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-hydroxyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (105) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-methoxy-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (106) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (107) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2R)-2-{phenylamino-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (108) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-methyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (109) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (110) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (111) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-aminocarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (112) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-hydroxyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (113) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (114) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methyl-4-phenyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (115) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2,5-dimethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (116) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-dimethylamino-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (117) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-{4-diethylamino-but-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (118) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-{dimethylamino-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (119) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin-2-yl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (120) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin-4-yl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (121) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{phenylamino-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (122) 5-chloro-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(4-ethyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (123) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (124) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (125) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (126) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (127) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (128) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (129) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (130) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (131) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (132) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (133) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (134) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (135) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (136) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (137) 5-bromo-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (138) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (139) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (140) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (141) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (142) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide,     the tautomers, the enantiomers, the diastereomers, the mixtures     thereof and the salts thereof, while the compounds -   (1) 5-chloro-thiophene-2-carboxylic     acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (2) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (3) 5-chloro-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (4) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (5) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (6) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (7) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (8) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (9) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (10) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (11) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (12) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-dimethylaminomethylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (13) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (14) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (15) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (16) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (17) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methypiperazin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (18) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methyl-1,4-diazepan-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (19) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (20) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (21) 5-bromo-thiophene-2-carboxylic     acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (22) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-butyl}-amide, -   (23) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyloxycarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (24) 5-bromo-thiophene-2-carboxylic     acid-N-{3-dimethylaminocarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (25) 5-bromo-thiophene-2-carboxylic     acid-N-{2-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (26) 5-bromo-thiophene-2-carboxylic     acid-N-{1-(thiophenyl-3-yl)-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide, -   (27) 5-bromo-thiophene-2-carboxylic     acid-N-{5-dimethylamino-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-pentyl}-amide, -   (28) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide, -   (29) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclohexyl}-amide, -   (30) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (31) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (32) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (33) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (34) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-4-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-piperazin-4-yl}-amide, -   (35) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (36) 5-chloro-thiophene-2-carboxylic     acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (37) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-1-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide, -   (38) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclobut-1-yl}-amide, -   (39) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (40) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[1-methyl-1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (41) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (42) 5-chloro-thiophene-2-carboxylic     acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (43) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-[1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (44) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (45) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (46) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-cyclopent-1-yl}-amide, -   (47) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (48) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (49) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (50) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (51) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (52) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (53) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (54) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (55) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (56) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (57) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (58) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (59) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (60) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (61) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (62) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (63) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (64) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiomorpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (65) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiazolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (66) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3,6-dihydro-2H-pyridin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (67) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(azepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (68) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (69) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (70) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (71) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin-4-yl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (72) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-{phenylamino-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (73) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (74) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (75) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (76) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (77) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (78) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (79) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (80) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (81) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (82) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (83) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (84) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (85) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (86) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (87) 5-bromo-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (88) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (89) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (90) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (91) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (92) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide,     the tautomers, the enantiomers, the diastereomers, the mixtures     thereof and the salts thereof are particularly preferred.

According to the invention the compounds of general formula I are obtained by methods known per se, for example by the following methods:

1) In order to prepare compounds of general formula

wherein A and R¹ to R⁶ are as hereinbefore defined:

-   i) acylation of a compound of general formula     Z¹-H  (II)     with a compound of general formula

while the following combinations of options for general formulae (II) and (III) result in compounds of general formula (I), and also result in the definitions of Z¹ and Z² for the particular combinations:

while in the above general formulae A and R¹ to R⁶ are as hereinbefore defined and Q denotes a hydroxy or C₁₋₄-alkoxy group, a halogen atom or an acyloxy group.

The acylation is conveniently carried out with a corresponding halide or anhydride in a solvent such as methylene chloride, chloroform, carbon tetrachloride, ether, tetrahydrofuran, dioxane, benzene, toluene, acetonitrile, dimethylformamide, sodium hydroxide solution or sulpholane, optionally in the presence of an inorganic or organic base at temperatures between −20 and 200° C., but preferably at temperatures between −10 and 160° C.

The acylation may however also be carried out with the free acid, optionally in the presence of an acid-activating agent or a dehydrating agent, e.g. in the presence of isobutyl chloroformate, thionyl chloride, trimethylchlorosilane, hydrogen chloride, sulphuric acid, methanesulphonic acid, p-toluenesulphonic acid, phosphorus trichloride, phosphorus pentoxide, N,N′-dicyclohexylcarbodiimide, N,N′-dicyclohexylcarbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole, N,N′-carbonyldiimidazole, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyl-uronium tetrafluoroborate/N-methylmorpholine, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyl-uronium tetrafluoroborate/N-ethyldiisopropylamine, O-pentafluorophenyl-N,N,N′,N′-tetramethyluronium-hexafluorophosphate/triethylamine, N,N′-thionyldiimidazole or triphenylphosphine/carbon tetrachloride, at temperatures between −20 and 200° C., but preferably at temperatures between −10 and 160° C.

-   ii) acylation of a compound of general formula (IIb), wherein A and     R¹ to R³ are as defined above, with a reactive carboxylic acid     derivative of general formula

wherein R⁴ to R⁶ are as defined above.

The acylation is conveniently carried out in a solvent or mixture of solvents such as dichloromethane, trichloromethan, carbon tetrachloride, benzene, chlorobenzene, toluene, xylene, hexamethyldisiloxane, ether, tetrahydrofuran, dioxane, acetonitrile, N-ethyl-diisopropylamine, N—C₁₋₅-alkylmorpholine, N—C₁₋₅-alkylpiperidine, N—C₁₋₅-alkylpyrrolidine, triethylamine, pyridine, optionally in the presence of a Lewis acid such as aluminium chloride, zinc iodide, zinc chloride, boron trifluoride, titanium(IV)chloride or trimethylaluminium at temperatures between −20 and 200° C., but preferably at temperatures between −10 and 160° C., for example using a microwave oven.

Compounds of general formula (XXIII) may conveniently be prepared from compounds of general formula (XXII) in a solvent or mixture of solvents such as dichloromethane, trichloromethan, carbon tetrachloride, benzene, chlorobenzene, toluene, xylene, hexamethyldisiloxan, ether, tetrahydrofuran, dioxane, acetonitrile, pyridine, optionally in the presence of N,N′-dicyclohexylcarbodiimide, N,N′-dicyclohexylcarbodiimide/N-hydroxysuccinimide or 1-hydroxy-benzotriazole, N,N′-carbonyldiimidazole, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyl-uronium tetrafluoroborate/N-methylmorpholine, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyl-uronium tetrafluoroborate/N-ethyldiisopropylamine, or in a solvent or mixture of solvents such as dichloromethane, trichloromethane, carbon tetrachloride, benzene, chlorobenzene, toluene, xylene, hexamethyldisiloxane, ether, tetrahydrofuran, dioxane, acetonitrile, formic acid, acetic acid, acetic anhydride or propionic acid, at temperatures between −20 and 200° C., but preferably at temperatures between −10 and 160° C.

Other methods of amide coupling are described for example in P. D. Bailey, I. D. Collier, K. M. Morgan in “Comprehensive Functional Group Interconversions”, Vol. 5, page 257ff., Pergamon 1995.

2) In order to prepare compounds of general formula (IIb):

-   a) Acylation of compounds of general formula     A—H  (IIa)     -   with compounds of general formula

-   -   where A and R¹ to R³ are as hereinbefore defined, Q denotes a         hydroxy or C₁₋₄-alkoxy group, a halogen atom or an acyloxy         group, and M¹ denotes a protective group which is optionally         subsequently cleaved.

The acylation is carried out as described for the cases shown in 1)i).

-   b) Acylation of compounds of general formula     A—H  (IIa)     -   with compounds of general formula

-   -   followed by reduction of the nitro group and optionally         reductive amination in order to introduce an alkyl group for R³,     -   while A and R¹ to R³ are as hereinbefore defined, Q denotes a         hydroxy or C₁₋₄-alkoxy group, a halogen atom or an acyloxy         group, and M¹ denotes a protective group which is subsequently         cleaved.

The acylation is carried out as described for the cases shown in 1)i). The reduction of the nitro group is conveniently carried out for example in a solvent or mixture of solvents such as water, aqueous ammonium chloride solution, hydrochloric acid, sulphuric acid, phosphoric acid, formic acid, acetic acid, acetic anhydride with base metals such as iron, zinc, tin or sulphur compounds such as ammonium sulphide, sodium sulphide or sodium dithionite or by catalytic hydrogenation with hydrogen, for example under a pressure between 0.5 and 100 bar, but preferably between 1 and 50 bar, or with hydrazine as reducing agent, conveniently in the presence of a catalyst such as for example Raney nickel, palladium charcoal, platinum oxide, platinum on mineral fibres or rhodium, or with complex hydrides such as lithium aluminium hydride, sodium borohydride, sodium cyanoborohydride, diisobutylaluminium hydride, conveniently in a solvent or mixture of solvents such as water, methanol, ethanol, isopropanol, pentane, hexane, cyclohexane, heptane, benzene, toluene, xylene, ethyl acetate, methylpropionate, glycol, glycoldimethyl ether, diethyleneglycol dimethyl ether, dioxane, tetrahydrofuran, N-methylpyrrolidinone, or N-ethyl-diisopropylamine, N—C₁₋₅-alkylmorpholine, N—C₁₋₅-alkylpiperidine, N—C₁₋₅-alkylpyrrolidine, triethylamine, pyridine, for example at temperatures between −30 and 250° C., but preferably between 0 and 150° C.

The reductive amination is conveniently carried out with the corresponding R³-aldehyde (formaldehyde or paraformaldehyde where R³=methyl, acetaldehyde or paraldehyde where R³=ethyl, propionaldehyde where R³=propyl) in a solvent or mixture of solvents such as methanol, ethanol, propanol, isopropanol, butanol, tetrahydrofuran, dioxane, diethyl ether, tert.-butyl-methyl-ether, ethyleneglycol dimethylether, diethyleneglycol dimethylether, sulpholane, dimethylformamide, N-methylpyrrolidinone, tetralin, dimethylsulphoxide, methylene chloride, chloroform or tetrachloromethane, for example at temperatures between −30 and 250° C., but preferably between −10 and 150° C., optionally in the presence of a base such as sodium methoxide, sodium ethoxide, sodium-tert.-butoxide, potassium-tert.-butoxide, sodium-tert.-butyldimethyl-silanoate, potassium hexamethyldisilazane, lithium diisopropylamide, potassium carbonate, rubidium carbonate, caesium carbonate, potassium phosphate, sodium hydride, optionally in the presence of a complexing agent such as 18-crown-6-ether, followed by reduction of the resulting imide by hydrogenation with hydrogen, for example under a pressure between 0.5 and 100 bar, but preferably between 1 and 50 bar, conveniently in the presence of a catalyst such as for example Raney nickel, palladium charcoal, platinum oxide, platinum on mineral fibres or rhodium, or with complex hydrides such as lithium aluminium hydride, sodium borohydride, sodium cyanborohydride, diisobutylaluminium hydride, for example at temperatures between −30 and 250° C., but preferably between 0 and 150° C.

3) In order to prepare compounds of general formula (IIc):

-   a) Acylation of compounds of general formula (IIb) with compounds of     general formula

-   -   where A and R¹ to R⁵ are as hereinbefore defined, Q denotes a         hydroxy or C₁₋₄-alkoxy group, a halogen atom or an acyloxy         group, and M¹ denotes a protective group which is optionally         subsequently cleaved.

The acylation is carried out as described for the cases in 1)i).

-   b) Acylation of compounds of general formula

-   -   with compounds of general formula (VI) optionally followed by         cleaving of the protective group M² and acylation of a compound         of general formula (IIa) by means of the compound thus obtained,         optionally followed by cleaving of the protective group M¹,     -   while A and R¹ to R⁵ are as hereinbefore defined, Q denotes a         hydroxy or C₁₋₄-alkoxy group, a halogen atom or an acyloxy         group, and both M¹ and M² denote protective groups.

The acylations are carried out as described in 1)i).

4) In order to prepare compounds of general formula (IIIb):

-   -   Acylation of compounds of general formula

-   -   with compounds of general formula (IIIc) optionally followed by         cleaving of the protective group M² and transformation into a         reactive carboxylic acid derivative of formula (IIIb),     -   where R⁴ to R⁶ are as hereinbefore defined, Q denotes a hydroxy         or C₁₋₄-alkoxy group, a halogen atom or an acyloxy group, and M²         denotes a protective group which is optionally subsequently         cleaved.

The acylation is carried out as described in 1)i).

5) In order to prepare compounds of general formula (IIIa):

-   a) Acylation of compounds of general formula (VII) with compounds of     general formula (IIIb),     -   where R¹ to R⁶ are as hereinbefore defined, Q denotes a hydroxy         or C₁₋₄-alkoxy group, a halogen atom or an acyloxy group, and M²         denotes a protective group which is optionally subsequently         cleaved.

The acylation is carried out as for the cases illustrated in 1)i).

-   b) Acylation of compounds of general formula (VII) with compounds of     general formula (VI) followed by cleaving of the protective group M¹     and acylation of the compound thus obtained with a compound of     general formula (IIIc) optionally followed by cleaving of the     protective group M², while R¹ to R⁶ are as hereinbefore defined, Q     in each case independently of one another denotes a hydroxy or     C₁₋₄-alkoxy group, a halogen atom or an acyloxy group, and both M¹     and M² denote protective groups.

The acylations are carried out as described in 1)i).

In the reactions described above any reactive groups present such as hydroxy, carboxy, amino, alkylamino or imino groups may be protected during the reaction by conventional protective groups which are cleaved again after the reaction.

For example a suitable protective group for a hydroxy group is the methoxy, benzyloxy, trimethylsilyl, acetyl, benzoyl, tert.-butyl, trityl, benzyl or tetrahydro-pyranyl group,

a suitable protective group for a carboxyl group is the trimethylsilyl, methyl, ethyl, tert.-butyl, benzyl or tetrahydropyranyl group and

a suitable protective group for an amino, alkylamino or imino group is the acetyl, trifluoroacetyl, benzoyl, ethoxycarbonyl, tert.-butoxycarbonyl, benzyloxycarbonyl, benzyl, methoxybenzyl or 2,4-dimethoxybenzyl group and additionally a suitable protective group for the amino group is the phthalyl group.

Other protective groups and their cleaving are described in T. W. Greene, P. G. M. Wuts, “Protective Groups in Organic Synthesis”, Wiley, 1991 and 1999.

Any protective group used is optionally subsequently cleaved for example by hydrolysis in an aqueous solvent, e.g. in water, isopropanol/water, tetrahydrofuran/water or dioxane/water, in the presence of an acid such as trifluoroacetic acid, hydrochloric acid or sulphuric acid or in the presence of an alkali metal base such as lithium hydroxide, sodium hydroxide or potassium hydroxide or by means of ether splitting, e.g. in the presence of iodotrimethylsilane, at temperatures between 0 and 100° C., preferably at temperatures between 10 and 50° C.

A benzyl, methoxybenzyl or benzyloxycarbonyl group, however, is cleaved by hydrogenolysis, for example, e.g. with hydrogen in the presence of a catalyst such as palladium/charcoal in a solvent such as methanol, ethanol, ethyl acetate, dimethylformamide, dimethylformamide/acetone or glacial acetic acid, optionally with the addition of an acid such as hydrochloric acid at temperatures between 0 and 50° C., but preferably at ambient temperature, and under a hydrogen pressure of 1 to 7 bar, but preferably 1 to 5 bar.

A methoxybenzyl group may also be cleaved in the presence of an oxidising agent such as cerium(IV)ammonium nitrate in a solvent such as methylene chloride, acetonitrile or acetonitrile/water at temperatures between 0 and 50° C., but preferably at ambient temperature.

A methoxy group is conveniently cleaved in the presence of boron tribromide in a solvent such as methylene chloride at temperatures between −35 and −25° C.

A 2,4-dimethoxybenzyl group, however, is preferably cleaved in trifluoroacetic acid in the presence of anisol.

A tert.-butyl or tert.-butyloxycarbonyl group is preferably cleaved by treatment with an acid such as trifluoroacetic acid or hydrochloric acid, optionally using a solvent such as methylene chloride, dioxane or ether.

A phthalyl group is preferably cleaved in the presence of hydrazine or a primary amine such as methylamine, ethylamine or n-butylamine in a solvent such as methanol, ethanol, isopropanol, toluene/water or dioxane at temperatures between 20 and 50° C.

An allyloxycarbonyl group is cleaved by treatment with a catalytic amount of tetrakis-(triphenylphosphine)-palladium(0), preferably in a solvent such as tetrahydrofuran and preferably in the presence of an excess of a base such as morpholine or 1,3-dimedone at temperatures between 0 and 100° C., preferably at ambient temperature and under inert gas, or by treatment with a catalytic amount of tris-(triphenylphosphine)-rhodium(I)chloride in a solvent such as aqueous ethanol and optionally in the presence of a base such as 1,4-diazabicyclo[2.2.2]octane at temperatures between 20 and 70° C.

Moreover, the compounds of general formula I obtained may be resolved into their enantiomers and/or diastereomers.

Thus, for example, the compounds of general formula I obtained which occur as racemates may be separated by methods known per se (cf. Allinger N. L. and Eliel E. L. in “Topics in Stereochemistry”, Vol. 6, Wiley Interscience, 1971) into their optical enantiomers and compounds of general formula I with at least 2 asymmetric carbon atoms may be resolved into their diastereomers on the basis of their physical-chemical differences using methods known per se, e.g. by chromatography and/or fractional crystallisation, and, if these compounds are obtained in racemic form, they may subsequently be resolved into the enantiomers as mentioned above.

The enantiomers are preferably separated by column separation on chiral phases or by recrystallisation from an optically active solvent or by reacting with an optically active substance which forms salts or derivatives such as e.g. esters or amides with the racemic compound, particularly acids and the activated derivatives or alcohols thereof, and separating the diastereomeric mixture of salts or derivatives thus obtained, e.g. on the basis of their differences in solubility, whilst the free antipodes may be released from the pure diastereomeric salts or derivatives by the action of suitable agents. Optically active acids in common use are e.g. the D- and L-forms of tartaric acid or dibenzoyltartaric acid, di-o-tolyltartaric acid, malic acid, mandelic acid, camphorsulphonic acid, glutamic acid, aspartic acid or quinic acid. An optically active alcohol may be, for example, (+) or (−)-menthol and an optically active acyl group in amides, for example, may be a (+)- or (−)-menthyloxycarbonyl.

Furthermore, the compounds of formula I may be converted into the salts thereof, particularly for pharmaceutical use into the physiologically acceptable salts with inorganic or organic acids. Acids which may be used for this purpose include for example hydrochloric acid, hydrobromic acid, sulphuric acid, methanesulphonic acid, phosphoric acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid or maleic acid.

Moreover, if the new compounds of formula I contain a carboxy group, they may subsequently, if desired, be converted into the salts thereof with inorganic or organic bases, particularly for pharmaceutical use into the physiologically acceptable salts thereof. Suitable bases for this purpose include for example sodium hydroxide, potassium hydroxide, cyclohexylamine, ethanolamine, diethanolamine and triethanolamine.

As already mentioned hereinbefore, the compounds of general formula I and the tautomers, enantiomers, diastereomers and physiologically acceptable salts thereof have valuable pharmacological properties, particularly an antithrombotic activity which is preferably based on an effect on thrombin or factor Xa, for example on a thrombin-inhibiting or factor Xa-inhibiting activity, on a prolonging effect on the aPTT time and/or on an inhibitory effect on related serine proteases such as e.g. urokinase, factor VIIa, factor IXa, factor XIa and factor XIIa.

The compounds listed in the Experimental Section were investigated for their effect on the inhibition of factor Xa as follows:

Method:

Enzyme-kinetic measurement with chromogenic substrate. The quantity of p-nitroaniline (pNA) released from the colourless chromogenic substrate by human factor Xa is determined photometrically at 405 nm. It is proportional to the activity of the enzyme used. The inhibition of the enzyme activity by the test substance (in relation to the solvent control) is determined at various concentrations of test substance and from this the IC₅₀ is calculated, as the concentration which inhibits the factor Xa used by 50%.

Material:

Tris(hydroxymethyl)-aminomethane buffer (100 mMol) and sodium chloride (150 mMol), pH 8.0 plus 1 mg/ml Human Albumin Fraction V, protease-free

Factor Xa (Calbiochem), spec. activity: 217 IU/mg, final concentration: 7 IU/ml for each reaction mixture

Substrate S 2765 (Chromogenix), final concentration: 0.3 mM/l (1 KM) for each reaction mixture

Test substance: final concentration 100, 30, 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003, 0.001 μMol/l

Procedure:

10 μl of a 23.5-times concentrated starting solution of the test substance or solvent (control), 175 μl of TRIS/HSA buffer and 25 μl of a 65.8 U/L Factor Xa working solution are incubated for 10 minutes at 37° C. After the addition of 25 μl of S 2765 working solution (2.82 mMol/l) the sample is measured in a photometer (SpectraMax 250) at 405 nm for 600 seconds at 37° C.

Evaluation:

1. Determining the maximum increase (deltaOD/minutes) over 21 measuring points.

2. Determining the % inhibition based on the solvent control.

3. Plotting a dosage/activity curve (% inhibition vs substance concentration).

4. Determining the IC₅₀ by interpolating the X-value (substance concentration) of the dosage/activity curve at Y=50% inhibition.

All the compounds tested had an IC₅₀ value of less than 100 μmol/L.

The compounds prepared according to the invention are generally well tolerated.

In view of their pharmacological properties the new compounds and the physiologically acceptable salts thereof are suitable for the prevention and treatment of venous and arterial thrombotic diseases, such as for example the prevention and treatment of deep leg vein thrombosis, for preventing reocclusions after bypass operations or angioplasty (PT(C)A), and occlusion in peripheral arterial diseases, and for preventing and treating pulmonary embolism, disseminated intravascular coagulation and severe sepsis, for preventing and treating DVT in patients with exacerbated COPD, for treating ulcerative colitic, for preventing and treating coronary thrombosis, for preventing stroke and the occlusion of shunts.

In addition, the compounds according to the invention are suitable for antithrombotic support in thrombolytic treatment, such as for example with alteplase, reteplase, tenecteplase, staphylokinase or streptokinase, for preventing long-term restenosis after PT(C)A, for the prevention and treatment of ischaemic incidents in patients with all forms of coronary heart disease, for preventing metastasis and the growth of tumours and inflammatory processes, e.g. in the treatment of pulmonary fibrosis, for preventing and treating rheumatoid arthritis, for preventing and treating fibrin-dependent tissue adhesions and/or the formation of scar tissue and for promoting wound healing processes.

In view of their pharmacological properties the new compounds and the physiologically acceptable salts thereof are also suitable for the treatment of Alzheimer's and Parkinson's disease. One explanation for this arises for example from the following findings, from which it can be concluded that thrombin inhibitors or factor Xa inhibitors, by inhibiting thrombin formation or thrombin activity, may be valuable drugs for treating Alzheimer's and Parkinson's disease. Clinical and experimental studies indicate that neurotoxic mechanisms, for example the inflammation which is associated with the activation of proteases of the clotting cascade, are involved in the dying of neurones following brain injury. Various studies point to the involvement of thrombin in neurodegenerative processes, for example following a stroke, repeated bypass operations or traumatic brain injury. An increased thrombin activity has been demonstrated some days after peripheral nerve damage, for example. It has also been shown that thrombin causes a neurite retraction, as well as glia proliferation, and apoptosis in primary cultures of neurones and neuroblastoma cells (for a summary see: Neurobiol. Aging 2004, 25(6), 783-793). Moreover, various in vitro studies on the brains of patients with Alzheimer's disease indicated that thrombin plays a role in the pathogenesis of this disease (Neurosci. Lett. 1992, 146, 152-54). A concentration of immune-reactive thrombin has been detected in neurite plaques in the brains of Alzheimer's patients. It has been demonstrated in vitro that thrombin also plays a part in the regulation and stimulation of the production of the “Amyloid Precursor Protein” (APP) as well as in the cleaving of the APP into fragments which can be detected in the brains of Alzheimer's patients. Moreover, it has been demonstrated that the thrombin-induced microglial activation leads in vivo to the degeneration of nigral dopaminergic neurones. These findings lead one to conclude that microglial activation, triggered by endogenous substance(s) such as thrombin, for example, are involved in the neuropathological process of the cell death of dopaminergic neurones of the kind which occurs in patients with Parkinson's disease (J. Neurosci. 2003, 23, 5877-86).

The dosage required to achieve such an effect is appropriately 0.01 to 3 mg/kg, preferably 0.03 to 1.0 mg/kg by intravenous route, and 0.03 to 30 mg/kg, preferably 0.1 to 10 mg/kg by oral route, in each case administered 1 to 4 times a day.

For this purpose, the compounds of formula I prepared according to the invention may be formulated, optionally together with other active substances, with one or more inert conventional carriers and/or diluents, e.g. with corn starch, lactose, glucose, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, water/ethanol, water/glycerol, water/sorbitol, water/polyethylene glycol, propylene glycol, cetylstearyl alcohol, carboxymethylcellulose or fatty substances such as hard fat or suitable mixtures thereof, to produce conventional galenic preparations such as plain or coated tablets, capsules, powders, suspensions or suppositories.

The new compounds and the physiologically acceptable salts thereof may be used therapeutically in conjunction with acetylsalicylic acid, with inhibitors of platelet aggregation such as fibrinogen receptor antagonists (e.g. abciximab, eptifibatide, tirofiban, roxifiban), with physiological activators and inhibitors of the clotting system and the recombinant analogues thereof (e.g. Protein C, TFPI, antithrombin), with inhibitors of ADP-induced aggregation (e.g. clopidogrel, ticlopidine), with P₂T receptor antagonists (e.g. cangrelor) or with combined thromboxane receptor antagonists/synthetase inhibitors (e.g. terbogrel).

The Examples that follow are intended to illustrate the invention, without restricting its scope:

EXPERIMENTAL SECTION

As a rule, melting points, IR, UV, ¹H-NMR and/or mass spectra have been obtained for the compounds prepared. Unless otherwise stated, R_(f) values were determined using ready-made silica gel 60 F_(254 s) TLC plates (E. Merck, Darmstadt, Item no. 1.05714) without chamber saturation. The R_(f) values given under the heading Alox were determined using ready-made aluminium oxide 60 F₂₅₄ TLC plates (E. Merck, Darmstadt, Item no. 1.05713) without chamber saturation. The R_(f) values given under the heading Reversed-phase-8 (RP-8) were determined using ready-made RP-8 F₂₅₄, TLC plates (E. Merck, Darmstadt, Item no. 1.15684) without chamber saturation. The ratios given for the eluants refer to units by volume of the solvents in question. For chromato-graphic purification silica gel made by Messrs Millipore (MATREX™, 35-70 my) was used. Unless more detailed information is provided as to the configuration, it is not clear whether the products are pure stereoisomers or mixtures of enantiomers and diastereomers.

The HPLC-MS 1 data were obtained under the following conditions:

Waters Alliance 2690 HPLC, Waters 2700 Autosampler, Waters 996 Diode array detector

The mobile phase used was:

A: water with 0.13% TFA

B: acetonitrile with 0.10% TFA

time in min % A % B flow rate in ml/min 0.0 95 5 1.00 0.1 95 5 1.00 3.1 2 98 1.00 4.5 2 98 1.00 5.0 95 5 1.00

The stationary phaase used was a Waters column, Xterra MS C₁₈ 2.5 μm, 4.6 mm×30 mm, (column temperature: constant at 25° C.).

The diode array detection was carried out at a wavelength range of 210-500 nm.

The HPLC-MS 2 data, where specified, were obtained under the following conditions:

HP 1100 with quaternary pump, Gilson G215 Autosampler, HP diode array detector, Waters ZQ2000 mass spectrometer.

The mobile phase used was:

A: water with 0.1% TFA

B: acetonitrile with 0.1% TFA

time in min % A % B flow rate in ml/min 0.00 95 5 1.0 0.40 95 5 1.0 4.00 2 98 1.0 4.35 2 98 1.0 4.50 95 5 1.0

The stationary phaase used was a Waters column, X-Terra™ MS C₁₈ 3.5 μm, 4.6 mm×50 mm (column temperature constant at 40° C.).

The diode array detection was carried out at a wavelength range from 210-550 nm

Range of mass-spectrometric detection: m/z 120 to m/z 1000.

The following abbreviations are used in the descriptions of the experiments:

-   Boc tert.-butoxycarbonyl -   DIPEA N-ethyl-diisopropylamine -   DMSO dimethylsulphoxide -   DMF N,N-dimethylformamide -   sat. saturated -   h hour(s) -   HATU     O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-hexafluorophosphate -   i. vac. in vacuo -   conc. concentrated -   min minute(s) -   NMM N-methyl-morpholine -   NMP N-methyl-pyrrolidin-2-one -   o ortho -   PfTU     O-pentafluorophenyl-N,N,N′,N′-tetramethyluronium-hexafluorophosphate -   PPA propanephosphonic acid cycloanhydride -   quant. quantitative -   R_(f) retention factor -   R_(t) retention time -   rac. racemic -   TBTU O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium -   tetrafluoroborate -   TEA triethylamine -   TFA trifluoroacetic acid -   THF tetrahydrofuran -   tert. tertiary -   Σ yield over all the steps carried out analogously as described

Example 1 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoly]-ethyl}-amide

(a) 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-1-nitro-benzene

9.92 g (49.2 mmol) 2-chloro-4-nitro-benzoic acid are combined with 16.94 g (52.8 mmol) TBTU and 18.4 ml DIPEA in 200 ml THF with stirring at ambient temperature and stirred for 15 min. Then 4.0 ml (3.41 g, 48.0 mmol) pyrrolidine are added and the mixture is stirred for 2 hours at ambient temperature. After evaporation i. vac. the residue is taken up in ethyl acetate, washed with 2-molar hydrochloric acid and sat. sodium hydrogen carbonate solution, dried over magnesium sulphate and evaporated down i. vac.

Yield: 11.56 g (95%)

R_(f) value: 0.49 (silica gel; dichloromethane/ethanol=19:1)

C₁₁H₁₁ClN₂O₃ (254.67)

Mass spectrum: (M+H)⁺=255/257 (chlorine isotope)

(b) 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline

10.10 g (40.0 mmol) 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-1-nitro-benzene is combined with 5 ml (5.15 g, 100 mmol) hydrazine hydrate in 150 ml of methanol and 2.00 g Raney nickel are added. While stirring at ambient temperature a total of 9 ml (9.29 g, 186 mmol) hydrazine hydrate and 9.00 g Raney nickel are added batchwise over 36 hours, then the mixture is filtered and the filtrate is evaporated down i. vac. The residue is taken up in acetone and filtered again. The filtrate is evaporated down i. vac., dissolved in acetone and cooled in the ice bath. The resulting precipitate is filtered off and dried at ambient temperature.

Yield: 6.20 g (69%)

R_(f) value: 0.34 (silica gel; dichloromethane/ethanol=19:1)

C₁₁H₁₃ClN₂O (224.69)

Mass spectrum: (M+H)⁺=225/227 (chlorine isotope)

(c) methyl 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate

Prepared analogously to Example 1a from methyl 5-chloro-thiophene-2-carboxylic acid and 2-aminopropionate with TBTU and NMM in THF.

Yield: 81%

R_(f) value: 0.63 (silica gel; petroleum ether/ethyl acetate=1:1)

C₉H₁₀ClNO₃S (247.70)

Mass spectrum: (M+H)⁺=248/250 (chlorine isotope)

(d) 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid

3.80 g (15.3 mmol) methyl 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate are suspended in 15.5 ml (15.5 mmol) 1-molar aqueous sodium hydroxide solution, combined with 15 ml of ethanol and then stirred for 4 hours at ambient temperature. After evaporation i. vac. the residue is combined with ice water, extracted with diethyl ether, the aqueous phase is poured into anice/acetic acid mixture and the resulting precipitate is suction filtered. After washing with water the precipitate is dried at 60° C.

Yield: 2.90 g (81%)

R_(f) value: 0.28 (silica gel; petroleum ether/ethyl acetate=1:2)

C₈H₈ClNO₃S (233.67)

(e) 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 1a from 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.

Yield: 77%

R_(f) value: 0.24 (silica gel; petroleum ether/ethyl acetate=1:2)

C₁₉H₁₉Cl₂N₃O₃S (440.34)

Mass spectrum: (M+H)⁺=440/442/444 (chlorine isotope)

Example 2 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoly]-ethyl}-amide

(a) (2R)-2-Boc-amino-3-methoxy-propionic acid

20 g (approx. 0.5 mol) sodium hydride is added batchwise to a mixture of 740 ml THF and 60 ml of methanol with cooling in a bath of isopropanol/dry ice and then stirred for 15 min at ambient temperature. 20.52 g (100 mmol) N-Boc-D-serine in 100 ml THF are combined with half the sodium methoxide solution thus obtained and stirred for one hour at ambient temperature under a nitrogen atmosphere. Then 10 ml (22.80 g, 0.16 mol) iodomethane are added and the mixture is again stirred for one hour at ambient temperature. Then the remaining half of the sodium methoxide solution is added, the mixture is again stirred for one hour at ambient temperature, and then 20 ml (45.60 g, 0.32 mol) iodomethane are added. The mixture is then stirred for 18 hours at ambient temperature under a nitrogen atmosphere. The reaction mixture is evaporated down i. vac., the residue is dissolved in water and extracted with diethyl ether. The aqueous phase is adjusted to pH 4 with citric acid solution and extracted with ethyl acetate. The combined organic phases are washed with sat. sodium chloride solution, dried over sodium sulphate and evaporated down i. vac. The residue is taken up in dichloromethane and water, extracted with dichloromethane, the combined organic phases are washed with sat. sodium chloride solution and dried over sodium sulphate. Then the mixture is evaporated down completely i. vac.

Yield: 6.15 g (28%)

R_(f) value: 0.45 (RP-8; methanol/5% sodium chloride solution=7:3)

C₉H₁₇NO₅ (219.24)

Mass spectrum: (M+H)⁺=220

(b) N-acetyl-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline

25.0 g (124 mmol) N-acetyl-4-amino-2-methyl-benzoic acid are combined with 3 drops DMF in 1000 ml dichloromethane and a solution of 21.0 ml (30.56 g, 241 mmol) oxalyl chloride in 100 ml TEA is added dropwise with stirring and cooling in the ice bath. Then the mixture is heated to 50° C. for 4.5 hours. The reaction mixture is filtered and the filtrate is evaporated down completely i. vac. The residue is taken up in 100 ml dichloromethane and this solution is added dropwise to a mixture of 10.4 ml (8.86 g, 125 mmol) pyrrolidine and 34.4 ml (25.0 g, 247 mmol) TEA in 500 ml dichloromethane with stirring and cooling in the ice bath. The mixture is stirred for 16 hours at ambient temperature. After filtering the filtrate is washed with 1-molar hydrochloric acid and sat. sodium chloride solution, combined with activated charcoal and dried over sodium sulphate. After evaporation i. vac. the residue is purified by chromatography on silica gel.

Yield: 9.50 g (31%)

R_(t) value: 3.32 min

C₁₄H₁₈N₂O₂ ₍246.31)

Mass spectrum: (M+H)⁺=247

(c) 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline

2.00 g (7.31 mmol) N-acetyl-2-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline in 50 ml 6-molar hydrochloric acid is heated to 105° C. for 25 min. The reaction mixture is poured into ice water, filtered, and sodium chloride and conc. ammonia solution are added to the filtrate until a pH of 9 is obtained. Then it is extracted with ethyl acetate. The combined organic phases are washed with semisat. and sat. sodium chloride solution, dried over sodium sulphate and evaporated down i. vac. The residue is combined with diethyl ether and triturated, the solid precipitate is suction filtered and dried in the air. The remaining product is obtained by evaporation of the mother liquor.

Yield: 1.20 g (70%)

R_(f) value: 0.50 (silica gel; ethyl acetate/ethanol=9:1+1% conc. ammonia solution)

C₁₂H₁₆N₂O (204.27)

Mass spectrum: (M+H)⁺=205

(d) (2R)-2-N-Boc-amino-3-methoxy-propionic acid-N′-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide

Prepared analogously to Example 1a from (2R)-2-N-Boc-amino-3-methoxy-propionic acid and 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF with subsequent purification by chromatography on silica gel.

Yield: 34%

R_(f) value: 0.55 (silica gel; dichloromethane/ethanol=9:1)

C₂₁H₃₁N₃O₅ (405.49)

Mass spectrum: (M+H)⁺=406

(e) (2R)-2-amino-3-methoxy-propionic acid-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide

200 mg (0.49 mmol) (2R)-2-N-Boc-amino-3-methoxy-propionic acid-N′-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide are combined with 0.5 ml trifluoroacetic acid in 10 ml dichloromethane and stirred for 20 hours at ambient temperature. After evaporation i. vac. the residue is taken up in dichloromethane and diethyl ether and evaporated down completely i. vac. The residue is stirred with a mixture of petroleum ether/diethyl ether 1:1 and then suction filtered.

Yield: 207 mg (99%)

R_(f) value: 0.55 (RP-8; 5% sodium chloride solution/methanol=7:3)

C₁₆H₂₃N₃O₃*CF₃COOH (419.40/305.38)

Mass spectrum: (M+H)⁺=306

(f) 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

81.3 mg (0.50 mmol) 5-chloro-thiophene-2-carboxylic acid are combined with one drop of DMF and 1 ml of thionyl chloride in 5 ml dichloromethane and refluxed for 2 hours. The mixture is then evaporated down completely i. vac., combined with dichloromethane and in each case evaporated down again completely. To the residue is added a mixture of 200 mg (0.48 mmol) (2R)-2-amino-3-methoxy-propionic acid-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide-trifluoroacetate combined with 0.21 ml (152 mg, 1.50 mmol) TEA in 15 ml dichloromethane and the mixture is stirred for 16 hours at ambient temperature. After evaporation i. vac. the residue is taken up in sat. sodium chloride solution and ethyl acetate and extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate, evaporated down completely i. vac., the residue is stirred with petroleum ether/diethyl ether 1:1, suction filtered and dried in the air.

Yield: 115 mg (51%)

R_(f) value: 0.55 (silica gel; dichloromethane/ethanol=9:1)

C₂₁H₂₄ClN₃O₄S (449.95)

Mass spectrum: (M+H)⁺=450/452 (chlorine isotope)

The following compounds may be prepared analogously:

-   (1) 5-chloro-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (2) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (3) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (4) 5-bromo-thiophene-2-carboxylic     acid-N-{(1R)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (5) 5-bromo-thiophene-2-carboxylic     acid-N-{(1S)-2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (6) 5-bromo-thiophene-2-carboxylic     acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide,

Example 3 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoly]-ethyl}-amide

(a) 2-N-Boc-amino-isobutyric acid-N′-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide

Prepared analogously to Example 1a from 2-N-Boc-amino-isobutyric acid and 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and TEA in DMF.

Yield: 66%

R_(f) value: 0.62 (silica gel; ethyl acetate/ethanol=9:1+1% conc. ammonia solution)

C₂₁H₃₁N₃O₄ (389.49)

(b) 2-amino-isobutyric acid-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide

1.10 g (2.82 mmol) 2-N-Boc-amino-isobutyric acid-N′-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide are combined with 15 ml 6-molar hydrochloric acid in 5 ml dioxane and stirred for one hour at ambient temperature. Then the mixture is extracted with diethyl ether, the aqueous phase is poured into in ice water and adjusted to approx. pH 9 with conc. ammonia. Then it is extracted with dichloromethane, the combined organic phases are dried over magnesium sulphate and evaporated down completely i. vac.

Yield: 680 mg (79%)

R_(f) value: 0.30 (silica gel; ethyl acetate/ethanol=9:1+1% conc. ammonia solution)

C₁₆H₂₃N₃O₂ ₍289.37)

(c) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 1a from 5-bromo-thiophene-2-carboxylic acid and 2-amino-isobutyric acid-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-amide with TBTU and NMM in THF.

Yield: 50%

R_(f) value: 0.52 (silica gel; ethyl acetate/ethanol=9:1+1% conc. ammonia solution)

C₂₁H₂₄BrN₃O₃S (478.40)

Mass spectrum: (M+H)⁺=479/481 (bromine isotope)

The following compounds were prepared analogously:

Structural formula Yield Mass peak(s) R_(f) value or R_(t) No. Name 4

Σ: 29% (M + H)⁺ = 434/436 (chlorine isotope) 0.52 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(pyrrolidin- 1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 11

Σ: 57% (M + H)⁺ = 490/492 (bromine isotope) 0.55 (silica gel; dichloromethane/ ethanol = 9:1) 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl- carbonyl)-phenylcarbamoyl]-cyclobut-1-yl)-amide 14

Σ: 16% (M + H)⁺ = 541/543 (bromine isotope) 2.43 min (HPLC-MS 1) 5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4- (pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl)-amide 15

Σ: 21% (M + H)⁺ = 497/499 (chlorine isotope) 2.41 min (HPLC-MS 1) 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-2-[pyridin-4-yl]-1-[3-methyl-4- (pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl)-amide 17

Σ: 44% (M + H)⁺ = 506/508 (bromine isotope) 0.58 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-bromo-thiophene-2-carboxylic acid-N-{3-[3-methyl-4-(pyrrolidin-1-yl- carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl)-amide 18

Σ: 23% (M + H)⁺ = 492/494 (bromine isotope) 0.40 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-bromo-thiophene-2-carboxylic acid-N-{3-[4-(pyrrolidin-1-yl-carbonyl)- phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide

The following compounds may be prepared analogously:

-   (1) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methylsulphanyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (2) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-butyl}-amide, -   (3) 5-bromo-thiophene-2-carboxylic     acid-N-{3-methyloxycarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (4) 5-bromo-thiophene-2-carboxylic     acid-N-{3-dimethylaminocarbonyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-propyl}-amide, -   (5) 5-bromo-thiophene-2-carboxylic     acid-N-{2-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (6) 5-bromo-thiophene-2-carboxylic     acid-N-{1-(thiophenyl-3-yl)-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide, -   (7) 5-bromo-thiophene-2-carboxylic     acid-N-{5-dimethylamino-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-pentyl}-amide, -   (8) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclohexyl}-amide,

Example 5 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoly]-1-methyl-ethyl}-amide

(a) tert.-butyl 2-[(5-bromo-thiophen-2-yl)-carbonylamino]-isobutyrate

2.63 g (12.3 mmol) 5-bromo-thiophene-2-carboxylic acid are refluxed in 15 ml dichloromethane together with 7.0 ml of thionyl chloride for 2 h with stirring. The mixture is then evaporated down i. vac. and the residue is twice taken up in toluene and evaporated down completely i. vac. The residue is added dropwise to 10 ml dichloromethane with stirring at ambient temperature in a mixture of 2.41 g (12.3 mmol) tert.-butyl 2-amino-isobutyrate hydrochloride in 20 ml dichloromethane with 5.14 ml (36.9 mmol) TEA and stirred for 16 h. The mixture is poured into water and extracted with dichloromethane, the combined organic phases are dried over magnesium sulphate and evaporated down i. vac.

Yield: 3.83 g (89%)

C₁₃H₁₈BrNO₃S (348.26)

Mass spectrum: (M+H)⁺=348/350 (bromine isotope)

(b) 2-[(5-bromo-thiophen-2-yl)-carbonylamino]-isobutyric acid

Prepared analogously to Example 2e from tert.-butyl 2-[(5-bromo-thiophen-2-yl)-carbonylamino]-isobutyrate with trifluoroacetic acid in dichloromethane.

Yield: 88%

R_(f) value: 0.33 (silica gel; dichloromethane/methanol=9:1)

C₉H₁₀BrNO₃S (292.15)

Mass spectrum: (M+H)⁺=292/294 (bromine isotope)

(c) 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-1-methyl-ethyl}-amide

350 mg (1.20 mmol) 2-[(5-bromo-thiophen-2-yl)-carbonylamino]-isobutyric acid are stirred together with 450 mg (1.18 mmol) HATU and 100 μl (0.91 mmol) NMM in 12 ml THF for 45 min at ambient temperature. Then 250 mg (1.11 mmol) 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline and a further 250 μl (2.27 mmol) NMM are added and the mixture is stirred for 4 h at 120° C. and 300 W radiation energy in a microwave oven. After standing for 11 h at ambient temperature the mixture is stirred for a further 2.5 h at 120° C. and 300 W radiation energy in the microwave oven. After evaporation i. vac. sat. sodium hydrogen carbonate solution is added and the mixture is extracted with ethyl acetate. The combined organic phases are washed with semisat. sodium chloride solution, extracted with 0.5-normal potassium hydrogen sulphaet solution and extracted with semisat. and sat. sodium chloride solution. After drying over sodium sulphate and evaporation i. vac. the residue is purified by chromatography on silica gel.

Yield: 235 mg (42%)

R_(f) value: 0.65 (silica gel; ethyl acetate/ethanol=9:1)

C₂₀H₂₁BrClN₃O₃S (498.82)

Mass spectrum: (M+H)⁺=498/500/502 (bromo- and chlorine isotope)

The following compound may be prepared analogously:

-   (1) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide,

Example 6 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-bromo-4-(pyrrolidine-1-carbonyl)-phenylcarbamoyl]-1-methyl-ethyl}-amide

(a) 3-bromo-4-(pyrrolidin-1-yl-carbonyl)-1-nitro-benzene

Prepared analogously to Example 1a from 2-bromo-4-nitro-benzoic acid and pyrrolidine with TBTU and NMM in DMF.

Yield: (77%)

R_(f) value: 0.25 (silica gel; petroleum ether/ethyl acetate=1:1)

C₁₁H₁₁BrN₂O₃ ₍299.12)

Mass spectrum: (M+Na)⁺=321/323 (bromine isotope)

(b) 3-bromo-4-(pyrrolidin-1-yl-carbonyl)-aniline

27.50 g (73.55 mmol) 3-bromo-4-(pyrrolidin-1-yl-carbonyl)-1-nitro-benzene are dissolved in 100 ml of ethyl acetate and combined with 2.5 g 10% Pd/C. The mixture is hydrogenated in a Parr apparatus at ambient temperature at 5 bar hydrogen pressure for two hours. Then the catalyst is filtered off and the filtrate is evaporated down i. vac. The residue is combined with petroleum ether, the precipitate is filtered off and dried.

Yield: 5.60 g (28%)

R_(f) value: 0.33 (silica gel; ethyl acetate/petroleum ether=9:1+1% conc. ammonia solution)

C₁₁H₁₃BrN₂O (269.14)

Mass spectrum: (M+Na)⁺=291/293 (bromine isotope)

(c) 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-bromo-4-(pyrrolidine-1-carbonyl)-phenylcarbamoyl]-1-methyl-ethyl}-amide

165.0 mg (0.57 mmol) 2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionic acid are combined with 215.0 mg (0.57 mmol) HATU and 60.0 μl (0.54 mmol) NMM in 6 ml THF with stirring at ambient temperature and stirred for 45 min. Then 150.0 mg (0.50 mmol) 3-bromo-4-(pyrrolidin-1-yl-carbonyl)-aniline and 100.0 μl (0.91 mmol) NMM are added and the mixture is stirred for 5 hours at 120° C. and 150 W radiation energy and stirred in a microwave oven. After evaporation i. vac. 0.5-normal potassium hydrogen sulphate solution is added and the mixture is extracted with ethyl acetate. The combined organic phases are washed with semisat. and sat. sodium chloride solution. After drying over magnesium sulphate and evaporation i. vac. the residue is purified by chromatography on silica gel (eluant gradient: ethyl acetate/ethanol=100:0->95:5).

Yield: 53.0 mg (19%)

R_(f) value: 0.65 (silica gel; ethyl acetate/ethanol=9:1)

C₂₀H₂₁Br₂N₃O₃S (543.27)

Mass spectrum: (M+H)⁺=542/544/546 (bromine isotope)

The following compounds may be prepared analogously:

-   (1) 5-chloro-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (2) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2,5-dihydropyrrol-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (3) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(thiazolidin-3-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (4) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-dimethylaminomethylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (5) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(3-fluorpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (6) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(2-methylpyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (7) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (8) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (9) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-chloro-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (10) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methypiperazin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (11) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-1-[3-methyl-4-(1-methyl-1,4-diazepan-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, -   (12) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methyl-4-(2,2-dimethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide, -   (13) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (14) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (15) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (16) 5-bromo-thiophene-2-carboxylic     acid-N-{4-[3-bromo-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydropyran-4-yl}-amide, -   (17) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-4-[3-trifluoromethyl-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-piperazin-4-yl}-amide, -   (18) 5-bromo-thiophene-2-carboxylic     acid-N-{1-methyl-4-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-piperazin-4-yl}-amide, -   (19) 5-bromo-thiophene-2-carboxylic     acid-N-{1-[3-methoxy-4-(2-oxo-piperazin-4-yl-carbonyl)-phenylcarbamoyl]-cycloheptyl}-amide, -   (20) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (21) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (22) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (23) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (24) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (25) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (26) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (27) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (28) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (29) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (30) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (31) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (32) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (33) 5-bromo-thiophene-2-carboxylic     acid-N-{3-[3-methyl-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (34) 5-bromo-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-((2S)-2-{pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (35) 5-chloro-thiophene-2-carboxylic     acid-N-{3-[3-chloro-4-(3-oxo-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-tetrahydrofuran-3-yl}-amide, -   (36) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(5-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (37) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-methyl-4-(3-oxo-[1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-bicyclo[2.2.1]hept-2-yl}-amide, -   (38) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[4-(4-formyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide, -   (39) 5-chloro-thiophene-2-carboxylic     acid-N-{2-[3-chloro-4-(4-acetyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-amide,

Example 7 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide

(a) methyl 1-[(5-bromo-thiophene-2-carbonyl)-amino]-cyclopentanecarboxylate

Prepared analogously to Example 2f from 5-bromo-thiophene-2-carboxylic acid and methyl 1-amino-cyclopentanecarboxylate with thionyl chloride and TEA in dichloromethane.

Yield: 87%

R_(f) value: 0.91 (silica gel; dichloromethane/methanol=9:1)

C₁₂H₁₄BrNO₃S (332.22)

Mass spectrum: (M+H)⁺=332/334 (bromine isotope)

(b) 1-[(5-bromo-thiophene-2-carbonyl)-amino]-cyclopentanecarboxylic acid

Prepared analogously to Example 1d from methyl 1-[(5-bromo-thiophene-2-carbonyl)-amino]-cyclopentanecarboxylate with 1-molar aqueous sodium hydroxide solution in methanol at 55° C.

Yield: 52%

R_(f) value: 0.31 (silica gel; dichloromethane/methanol=9:1)

C₁₁H₁₂BrNO₃S (318.19)

Mass spectrum: (M+H)⁺=318/320 (bromine isotope)

(c) 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-cyclopentyl}-amide

257.0 mg (0.81 mmol) 1-[(5-bromo-thiophene-2-carbonyl)-amino]-cyclopentanecarboxylic acid are combined with 307.0 mg (0.81 mmol) HATU and 202.0 μl (1.84 mmol) NMM in 2 ml DMF with stirring at ambient temperature and stirred for 30 min. Then 150.0 mg (0.73 mmol) (3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline are added and the mixture is stirred overnight at 85° C. Sodium hydrogen carbonate solution is added to the reaction mixture and extracted with ethyl acetate. The combined organic phases are washed with 0.5-molar potassium hydrogen sulphate solution and sat. sodium chloride solution. After drying over magnesium sulphate and evaporation i. vac. the residue is purified by chromatography on silica gel (eluant gradient: dichloromethane/methanol=98:2->90:10).

Yield: 205.0 mg (55%)

R_(f) value: 0.45 (silica gel; dichloromethane/methanol=9:1)

C₂₃H₂₆BrN₃O₃S (504.44)

Mass spectrum: (M+H)⁺=504/506 (bromine isotope)

Example 8 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-1-[3-chloro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) tert.-butyl(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate

Prepared analogously to Example 1a from tert.-butyl 5-chloro-thiophene-2-carboxylic acid and (R)-2-amino-propionate with TBTU and NMM in THF.

Yield: 98%

R_(f) value: 0.75 (silica gel; petroleum ether/ethyl acetate=1:1)

C₁₂H₁₆ClNO₃S (289.78)

(b) (R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid

Prepared analogously to Example 2e from tert.-butyl(R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionate with TFA in dichloromethane.

Yield: 69%

R_(f) value: 0.0-0.3 (silica gel; ethyl acetate/petroleum ether=4:1)

C₈H₈ClNO₃S (233.67)

Mass spectrum: (M+H)⁺=234/236 (chlorine isotope)

(c) 5-chloro-thiophene-2-carboxylic acid-N-{(R)-1-[3-chloro-4-(pyrrolidine-1-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 1a from (R)-2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid and 3-chloro-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.

Yield: 23%

R_(f) value: 0.2 (silica gel; ethyl acetate+1% conc. ammonia solution)

C₁₉H₁₉Cl₂N₃O₃S (440.34)

Mass spectrum: (M+H)⁺=438/440/442 (chlorine isotope)

Example 9 5-chloro-thiophene-2-carboxylic acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) 2-tert.-butoxycarbonylamino-3-methoxy-propionic acid

1.90 g (16.0 mmol) 2-amino-3-methoxy-propionic acid in 30 ml dioxane and 12.5 ml of water are combined with a solution of 7.10 g (32.5 mmol) di-tert.-butyldicarbonate in 20 ml 1,4-dioxane and stirred for 4.5 hours at 40° C. At ambient temperature 20 ml 2-molar aqueous sodium hydroxide solution is added and the mixture is stirred overnight. After filtering the filtrate is extracted with ethyl acetate. The aqueous phase is adjusted to pH 3.5 with acetic acid and extracted with ethyl acetate. The combined organic phases are washed with semisat. and sat. sodium chloride solution, dried over magnesium sulphate and evaporated down i. vac.

Yield: 2.10 g (60%)

C₉H₁₇NO₅ (219.24)

Mass spectrum: (M−H)-=218

(b) 2-Boc-amino-3-methoxy-N-[3-methyl-4-(pyrrolidine-1-carbonyl)-phenyl]-propionic acid-amide

Prepared analogously to Example 1a from 2-tert.-butoxycarbonylamino-3-methoxy-propionic acid and 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and NMM in DMF.

Yield: quant.

R_(f) value: 0.55 (silica gel; ethyl acetate/ethanol=9:1)

C₂₁H₃₁N₃O₅ ₍405.49)

Mass spectrum: (M+H)⁺=406

(c) 2-amino-3-methoxy-N-[3-methyl-4-(pyrrolidine-1-carbonyl)-phenyl]-propionic acid-amide

Prepared analogously to Example 3b from 2-Boc-amino-3-methoxy-N-[3-methyl-4-(pyrrolidine-1-carbonyl)-phenyl]-propionic acid-amide and 6-molar hydrochloric acid in dioxane.

Yield: 74%

R_(f) value: 0.1 (silica gel; ethyl acetate/ethanol=9:1)

C₁₆H₂₃N₃O₃ (305.37)

(d) 5-chloro-thiophene-2-carboxylic acid-N-{2-methoxy-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 1a from 5-chloro-thiophene-2-carboxylic acid and 2-amino-3-methoxy-N-[3-methyl-4-(pyrrolidine-1-carbonyl)-phenyl]-propionamide with TBTU and TEA in DMF.

Yield: (60%)

R_(f) value: 0.45 (silica gel; ethyl acetate/ethanol=9:1)

C₂₁H₂₄ClN₃O₅S (449.95)

Mass spectrum: (M+H)⁺=450/452 (chlorine isotope)

Example 10 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-1-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide

(a) ethyl(R)-[(5-chloro-thiophene-2-carbonyl)-amino]-phenyl-acetate

Prepared analogously to Example 1a from 5-chloro-thiophene-2-carboxylic acid and ethyl(R)-amino-phenyl-acetate with TBTU and NMM in THF.

Yield: 96%

R_(f) value: 0.61 (silica gel; dichloromethane/ethanol=98:2)

C₁₅H₁₄ClNO₃S (323.80)

Mass spectrum: (M+H)⁺=324/326 (chlorine isotope)

(b) (R)-[(5-chloro-thiophene-2-carbonyl)-amino]-phenyl-acetic acid

Prepared analogously to Example 1d from ethyl(R)-[(5-chloro-thiophene-2-carbonyl)-amino]-phenyl-acetate with 1-molar aqueous sodium hydroxide solution in ethanol.

Yield: 96%

R_(f) value: 0.10 (silica gel; dichloromethane/ethanol=9:1)

C₁₃H₁₀ClNO₃S (295.74)

Mass spectrum: (M+H)⁺=296/298 (chlorine isotope)

(c) 5-chloro-thiophene-2-carboxylic acid-N-{(1R)-1-phenyl-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-methyl}-amide

300.0 mg (1.01 mmol) (R)-[(5-chloro-thiophene-2-carbonyl)-amino]-phenyl-acetic acid, 207.0 mg (1.01 mmol) (3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline and 335.0 μl (3.04 mmol) NMM in 60 ml dichloromethane are combined at 0° C. with 1.19 ml (2.03 mmol) PPA (50% in ethyl acetate) and stirred overnight at ambient temperature. After evaporation i. vac. the residue is purified by chromatography on silica gel (eluant gradient: dichloromethane/ethanol=100:0->94:6).

Yield: 180.0 mg (37%)

R_(f) value: 0.61 (silica gel; dichloromethane/ethanol=9:1)

C₂₅H₂₄ClN₃O₃S (482.00)

Mass spectrum: (M+H)⁺=482/484 (chlorine isotope)

Example 12 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) 4-(pyrrolidin-1-yl-carbonyl)-nitro-benzene

Prepared analogously to Example 1a from 4-nitrobenzoic acid and pyrrolidine with TBTU and TEA in THF.

Yield: quant.

R_(f) value: 0.36 (silica gel; dichloromethane/ethanol=95:5)

C₁₁H₁₂N₂O₃ ₍220.23)

Mass spectrum: (M+H)⁺=221

(b) 4-(pyrrolidin-1-yl-carbonyl)-aniline

Prepared analogously to Example 6b from 4-(pyrrolidin-1-yl-carbonyl)-nitro-benzene by hydrogenation with hydrogen with Pd/C 10% in methanol.

Yield: quant.

R_(f) value: 0.33 (silica gel; dichloromethane/ethanol=95:5)

C₁₁H₁₄N₂O (190.24)

Mass spectrum: (M+H)⁺=191

(c) 5-bromo-thiophene-2-carboxylic acid-N-{-1-methyl-1-[4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 10c from 2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionic acid and 4-(pyrrolidin-1-yl-carbonyl)-aniline with PPA and NMM in dichloromethane.

Yield: 65%

R_(f) value: 0.26 (silica gel; dichloromethane/ethanol=95:5)

C₂₀H₂₂BrN₃O₃S (464.38)

Mass spectrum: (M+H)⁺=464/466 (bromine isotope)

Example 13 5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[1-methyl-1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) (2R)-2-Boc-amino-3-(1-methyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionic acid-amide

Prepared analogously to Example 1a from (R)-2-tert.-butoxycarbonylamino-3-(1-methyl-1H-imidazol-4-yl)-propionic acid and 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and DIPEA in THF.

Yield: quant.

R_(f) value: 0.66 (silica gel; dichloromethane/ethanol=8:2)

C₂₄H₃₃N₅O₄ (455.55)

Mass spectrum: (M+H)⁺=456

(b) (2R)-2-amino-3-(1-methyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide-triflate

Prepared analogously to Example 2e from (2R)-2-Boc-amino-3-(1-methyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionic acid-amide with TFA in dichloromethane.

Yield: 57%

R_(f) value: 0.20 (silica gel; dichloromethane/ethanol=8:2)

C₁₉H₂₅N₅O₂*CF₃COOH (469.46/355.44)

Mass spectrum: (M+CF₃COO)⁻=468

(c) 5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[1-methyl-1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 10c from 5-bromo-thiophene-2-carboxylic acid and (2R)-2-amino-3-(1-methyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidine-1-carbonyl)-phenyl]-propionamide-triflate with PPA and NMM in THF.

Yield: 52%

R_(f) value: 0.40 (silica gel; dichloromethane/ethanol=9:1)

C₂₄H₂₆BrN₅O₃S (544.47)

Mass spectrum: (M+H)⁺=544/546 (bromine isotope)

Example 16 5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) (R)-2-Boc-amino-3-(1-benzyl-1H-imidazol-4-yl]-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionic acid-amide

Prepared analogously to Example 1a from (R)-3-(1-benzyl-1H-imidazol-4-yl)-2-tert.-butoxycarbonylamino-propionic acid and 3-methyl-4-(pyrrolidin-1-yl-carbonyl)-aniline with TBTU and DIPEA in THF.

Yield: quant.

R_(f) value: 0.56 (silica gel; dichloromethane/ethanol=9:1)

C₃₀H₃₇N₅O₄ ₍531.65)

Mass spectrum: (M+H)⁺=532

(b) (R)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide

Prepared analogously to Example 2e from (R)-2-Boc-amino-3-(1-benzyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionic acid-amide with TFA in dichloromethane.

Yield: 88%

R_(f) value: 0.15 (silica gel; dichloromethane/ethanol=9:1)

C₂₅H₂₉N₅O₂ ₍431.53)

Mass spectrum: (M+H)⁺=432

(c) (R)-2-amino-3-(1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide

350.0 mg (0.81 mmol) (R)-2-amino-3-(1-benzyl-1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide are dissolved in 10.0 ml acetic acid and combined with 150.0 mg Pd(OH)₂. The mixture is hydrogenated in a Parr apparatus at ambient temperature at 3 bar hydrogen pressure for eight hours. Then the catalyst is filtered off and the filtrate is evaporated down i. vac.

Yield: 210 mg (76%)

C₁₈H₂₃N₅O₂ (341.41)

Mass spectrum: (M+H)⁺=342

(d) 5-bromo-thiophene-2-carboxylic acid-N-{(1R)-2-[1H-imidazol-4-yl]-1-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 10c from 5-bromo-thiophene-2-carboxylic acid and (R)-2-amino-3-(1H-imidazol-4-yl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-propionamide with PPA and NMM in THF.

Yield: 4%

R_(t) value: 5.5 min (HPLC-MS 2)

C₂₃H₂₄BrN₅O₃S (530.44)

Mass spectrum: (M+H)⁺=530/532 (bromine isotope)

Example 19 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-cyclopent-1-yl}-amide

(a) N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide

Prepared analogously to Example 1a from 4-acetylamino-2-methyl-benzoic acid and morpholine with TBTU and TEA in THF.

Yield: 66%

R_(f) value: 0.35 (silica gel; dichloromethane/methanol=9:1)

C₁₄H₁₈N₂O₃ ₍262.30)

Mass spectrum: (M+H)⁺=263

(b) 3-methyl-4-(morpholin-4-yl-carbonyl)-aniline

700.0 mg (2.67 mmol) N-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenyl]-acetamide are combined with 7 ml 4-molar sodium hydroxide solution and stirred overnight at 65° C. The reaction mixture is poured onto ice water and extracted with ethyl acetate. The organic phase is dried over magnesium sulphate and evaporated down i. vac.

Yield: 580.0 mg (99%)

C₁₂H₁₆N₂O₂ (220.27)

Mass spectrum: (M+H)⁺=221

(c) 5-bromo-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(morpholin-4-yl-carbonyl)-phenylcarbamoyl]-cyclopent-1-yl}-amide

Prepared analogously to Example 7c from 1-[(5-bromo-thiophene-2-carbonyl)-amino]-cyclopentanecarboxylic acid and 3-methyl-4-(morpholin-4-yl-carbonyl)-aniline with HATU and NMM in DMF.

Yield: 49%

R_(f) value: 0.27 (silica gel; dichloromethane/methanol=9:1)

C₂₃H₂₆BrN₃O₄S (520.44)

Mass spectrum: (M+H)⁺=520/522 (bromine isotope)

Example 20 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) 2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-aniline

Prepared analogously to Example 1a from 4-amino-3-fluoro-benzoic acid and pyrrolidine with TBTU and TEA in DMF.

Yield: 58%

R_(f) value: 0.70 (silica gel; ethyl acetate)

C₁₁H₁₃FN₂O (208.23)

Mass spectrum: (M+H)⁺=209

(b) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 7c from 2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionic acid and 2-fluoro-4-(pyrrolidin-1-yl-carbonyl)-aniline with HATU and NMM in DMF.

Yield: 4%

R_(f) value: 0.53 (silica gel; ethyl acetate)

C₂₀H₂₁BrFN₃O₃S (482.37)

Mass spectrum: (M+H)⁺=482/484 (bromine isotope)

Example 21 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

(a) methyl 4-amino-2-methyl-benzoate

20.0 g (0.10 mol) 4-acetylamino-2-methyl-benzoic acid in 200 ml of methanol are combined with 15 ml (0.28 mol) conc. sulphuric acid and refluxed for 3 hours with stirring. After evaporation i. vac. the residue is poured onto ice water and adjusted to pH 9 with sodium hydrogen carbonate solution. The precipitate is filtered off and dried at 40° C. in the vacuum drying cupboard.

Yield: 15.1 g (88%)

R_(f) value: 0.81 (silica gel; dichloromethane/methanol 9:1)

C₉H₁₁NO₂ (165.19)

Mass spectrum: (M+H)⁺=166

(b) 4-{2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid-methylester

Prepared analogously to Example 7c from 2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionic acid and methyl 4-amino-2-methyl-benzoate with HATU and NMM in DMF.

Yield: 80%

R_(f) value: 0.62 (silica gel; dichloromethane/methanol 9:1)

C₁₈H₁₉BrN₂O₄S (439.33)

Mass spectrum: (M+H)⁺=439/441 (bromine isotope)

(c) 4-{2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid

Prepared analogously to Example 1d from methyl 4-{2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoate with 1-molar sodium hydroxide solution in methanol.

Yield: 69%

R_(f) value: 0.31 (silica gel; dichloromethane/methanol 9:1)

C₁₇H₁₇BrN₂O₄S (425.30)

Mass spectrum: (M+H)⁺=425/427 (bromine isotope)

(d) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2-hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Prepared analogously to Example 1a from 4-{2-[(5-bromo-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid and (S)-2-hydroxymethyl-pyrrolidine with TBTU and TEA in DMF.

Yield: 46%

R_(f) value: 0.70 (silica gel; ethyl acetate/ethanol 8:2+1% acetic acid)

C₂₂H₂₆BrN₃O₄S (508.43)

Mass spectrum: (M+H)⁺=508/510 (bromine isotope)

The following compounds were prepared analogously:

Structural formula Yield Mass peak(s) R_(f) value or R_(t) No. Name 22

Σ: 18% (M + H)⁺ = 522/524 (bromine isotope) 0.52 (silica gel; ethyl acetate/ethanol = 8:2 + 1% acetic acid) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 23

Σ: 11% (M + H)⁺ = 561/563 (bromine isotope) 0.38 (RP-(C18); 5% NaCl solution/ methanol = 2:3) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- {pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 24

Σ: 18% (M + H)⁺ = 507/509 (bromine isotope) 0.42 (silica gel; ethyl acetate/ethanol = 8:2 + 1% acetic acid) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-oxo- piperazln-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 25

Σ: 12% (M + H)⁺ = 521/523 (bromine isotope) 0.33 (silica gel; ethyl acetate/ethanol = 8:2 + 1% acetic acid) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(5-oxo- [1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 26

Σ: 15% (M + H)⁺ = 521/523 (bromine isotope) 0.32 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-oxo- [1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 27

Σ: 16% (M + H)⁺ = 521/523 (bromine isotope) 0.41 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-formyl- piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 28

Σ: 16% (M + H)⁺ = 535/537 (bromine isotope) 0.39 (silica gel; ethyl acetate/ethanol = 9:1 + 1% ammonia) 5-bromo-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl- piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, 29

Σ: 22% (M + H)⁺ = 464/466 (chlorine isotope) 0.59 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, 30

Σ: 30% (M + H)⁺ = 478/480 (chlorine isotope) 0.58 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, 31

Σ: 16% (M + H)⁺ = 517/519 (chlorine isotope) 0.39 (RP-(C18); 5% NaCl solution/ methanol = 2:3) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- {pyrrolidin-1-yl-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide, 32

Σ: 1% (M + H)⁺ = 463/465 (chlorine isotope) 0.36 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, 33

Σ: 32% (M + H)⁺ = 477/479 (chlorine isotope) 0.34 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(5-oxo- [1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide, 34

Σ: 32% (M + H)⁺ = 477/479 (chlorine isotope) 0.32 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-oxo- [1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 35

Σ: 30% (M + H)⁺ = 477/479 (chlorine isotope) 0.35 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-formyl- piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 36

Σ: 32% (M + H)⁺ = 491/493 (chlorine isotope) 0.34 (silica gel; ethyl acetate/ethanol = 8:2 + 1% ammonia) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-acetyl- piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

Example 37 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{3-hydroxy-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

200 μl of a 0.05 molar solution of 4-{2-[(5-chloro-thiophene-2-carbonyl)-amino]-2-methyl-propionylamino}-2-methyl-benzoic acid, which additionally contains 0.05 mol/l DIPEA, in DMF are combined with 100 μl of a 0.1-molar solution of TBTU in DMF on a microtitre plate and mixed for 10 mins on a shaker. Then 200 μl of a 0,05-molar solution of (3-hydroxy-prop-1-yl)-piperidine, which additionally contains 0.05 mol/l DIPEA, are pipetted in and again mixed in by shaking. After 16 h at ambient temperature the mixture is filtered through basic aluminium oxide and washed with DMF/methanol=9:1. Then it is evaporated down i. vac.

R_(t) value: 3.77 min (HPLC-MS 2)

C₂₅H₃₂ClN₃O₄S (506.06)

Mass spectrum: (M+H)⁺=507.07

The following compounds were prepared analogously:

Structural formula Mass peak(s) R_(f) value or R_(t) No. Name 38

(M + H)⁺ = 483.03 3.35 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(1-oxo- thiomorpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 39

(M + H)⁺ = 509.00 3.51 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S,4R)- 2-methoxycarbonyl-4-hydroxy-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]- ethyl}-amide 40

(M + H)⁺ = 477.05 4.35 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3,5- dimethyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 41

(M + H)⁺ = 492.02 3.36 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-(3-methyl-4-(4- aminocarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 42

(M + H)⁺ = 463.02 4.17 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-methyl- piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 43

(M + H)⁺ = 463.02 4.19 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-methyl- piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 44

(M + H)⁺ = 563.14 3.83 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-{3-butyl- ureido}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 45

(M + H)⁺ = 506.05 3.56 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- {dimethylaminocarbonyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 46

(M + H)⁺ = 492.02 3.46 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- {methylaminocarbonyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 47

(M + H)⁺ = 507.03 4.09 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2- methoxycarbonyl-piperidun-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 48

(M + H)⁺ = 477.99 3.42 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2R)-2- aminocarbonyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 49

(M + H)⁺ = 584.18 3.94 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-{1-butyl- sulphonylamino}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 50

(M + H)⁺ = 465.98 3.20 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4- hydroxy-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 51

(M + H)⁺ = 493.00 3.86 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2- methoxycarbonyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 52

(M + H)⁺ = 526.08 3.35 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin- 3-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 53

(M + H)⁺ = 548.17 3.44 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{4- dimethylamino-but-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 54

(M + H)⁺ = 464.99 3.58 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2R)-2- hydroxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 55

(M + H)⁺ = 467.03 3.95 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4- (thiomorpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 56

(M + H)⁺ = 464.99 3.78 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-methyl- morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 57

(M + H)⁺ = 479.02 3.89 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2R)-2- methoxymethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 58

(M + H)⁺ = 548.17 3.43 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{2- diethylamino-eth-1-yl)-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide, 59

(M + H)⁺ = 478.04 3.14 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-methyl- [1,4]diazepan-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 60

(M + H)⁺ = 453.01 3.90 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4- (thiazolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 61

(M + H)⁺ = 446.98 3.97 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3,6- dihydro-2H-pyridin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 62

(M + H)⁺ = 463.02 4.11 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(azepan-1- yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 63

(M + H)⁺ = 477.05 4.29 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3,3- dimethyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 64

(M + H)⁺ = 477.05 4.27 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-ethyl- piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 65

(M + H)⁺ = 521.06 4.07 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-ethyl- piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 66

(M + H)⁺ = 520.12 3.36 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3- ethoxycarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 67

(M + H)⁺ = 534.14 3.38 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{3- dimethylamino-prop-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl} amide 68

(M + H)⁺ = 546.15 3.42 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2- {piperidin-1-yl-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 69

(M + H)⁺ = 521.06 3.97 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2- {methoxy-carbonyl-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]- ethyl}-amide 70

(M + H)⁺ = 464.99 3.52 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3- hydroxyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 71

(M + H)⁺ = 479.02 3.79 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4- methoxy-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 72

(M + H)⁺ = 448.99 3.94 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-methyl- pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 73

(M + H)⁺ = 540.11 3.82 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2R)-2- {phenylamino-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 74

(M + H)⁺ = 464.01 3.12 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4-methyl- piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 75

(M + H)⁺ = 448.99 4.01 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(piperidin- 1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 76

(M + H)⁺ = 463.02 4.13 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-methyl- piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 77

(M + H)⁺ = 492.02 3.44 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3- aminocarbonyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 78

(M + H)⁺ = 464.99 3.43 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4- hydroxyl-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 79

(M + H)⁺ = 450.97 3.64 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4- (morpholin-4-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 80

(M + H)⁺ = 525.09 4.41 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxyiic acid-N-{1-methyl-1-[3-methyl-4-(2-methyl- 4-phenyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 81

(M + H)⁺ = 463.02 4.09 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2,5- dimethyl-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 82

(M + H)⁺ = 478.04 3.12 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3- dimethylamino-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 83

(M + H)⁺ = 576.22 3.50 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(3-{4- diethylamino-but-1-yl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 84

(M + H)⁺ = 506.09 3.16 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(4- {dimethylamino-methyl}-piperidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide 85

(M + H)⁺ = 512.05 3.30 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin- 2-yl)-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 86

(M + H)⁺ = 512.05 3.26 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-(2-{pyridin- 4-yl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide 87

(M + H)⁺ = 540.11 3.82 min (HPLC-MS 2) 5-chloro-thiophene-2-carboxylic acid-N-{1-methyl-1-[3-methyl-4-((2S)-2- {phenylamino-methyl}-pyrrolidin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}- amide

Example 88 5-chloro-thiophene-2-carboxylic acid-N-{1-[3-methyl-4-(4-ethyl-piperazin-1-yl-carbonyl)-phenylcarbamoyl]-ethyl}-amide

200 μl of a 0.05-molar solution of 2-[(5-chloro-thiophene-2-carbonyl)-amino]-propionic acid, which additionally contains 0.05 mol/l DIPEA, in DMF are combined with 100 μl of a 0.1-molar solution of HATU in DMF on a microtitre plate and mixed for 10 min on a shaker. Then 200 μl of a 0.05-molar solution of 4-(4-ethyl-piperazin-1-yl-carbonyl)-aniline which additionally contains 0.05 mol/l DIPEA are pipetted in and the mixture is again combined by jogging. After 16 h at 80° C. the mixture is filtered through basic aluminium oxide and washed again with DMF/methanol=9:1. Then it is evaporated down i. vac.

R_(t) value: 3.10 min (HPLC-MS 2)

C₂₁H₂₅ClN₄O₃S (448.98)

Mass spectrum: (M+H)⁺=449

The Examples that follow describe the preparation of pharmaceutical formulations which contain as active substance any desired compound of general formula I:

Example I Dry Ampoule Containing 75 mg of Active Substance Per 10 ml

Composition:

Active substance 75.0 mg Mannitol 50.0 mg water for injections ad 10.0 ml Preparation:

Active substance and mannitol are dissolved in water. After packaging the solution is freeze-dried. To produce the solution ready for use for injections, the product is dissolved in water.

Example II Dry Ampoule Containing 35 mg of Active Substance Per 2 ml

Composition:

Active substance 35.0 mg Mannitol 100.0 mg water for injections ad 2.0 ml Preparation:

Active substance and mannitol are dissolved in water. After packaging, the solution is freeze-dried.

To produce the solution ready for use for injections, the product is dissolved in water.

Example III Tablet Containing 50 mg of Active Substance

Composition:

(1) Active substance 50.0 mg (2) Lactose 98.0 mg (3) Maize starch 50.0 mg (4) Polyvinylpyrrolidone 15.0 mg (5) Magnesium stearate  2.0 mg 215.0 mg  Preparation:

(1), (2) and (3) are mixed together and granulated with an aqueous solution of (4). (5) is added to the dried granulated material. From this mixture tablets are pressed, biplanar, faceted on both sides and with a dividing notch on one side. Diameter of the tablets: 9 mm.

Example IV Tablet Containing 350 mg of Active Substance

Composition:

(1) Active substance 350.0 mg (2) Lactose 136.0 mg (3) Maize starch  80.0 mg (4) Polyvinylpyrrolidone  30.0 mg (5) Magnesium stearate  4.0 mg 600.0 mg Preparation: (1), (2) and (3) are mixed together and granulated with an aqueous solution of (4). (5) is added to the dried granulated material. From this mixture tablets are pressed, biplanar, faceted on both sides and with a dividing notch on one side. Diameter of the tablets: 12 mm.

Example V Capsules Containing 50 mg of Active Substance

Composition:

(1) Active substance 50.0 mg (2) Dried maize starch 58.0 mg (3) Powdered lactose 50.0 mg (4) Magnesium stearate  2.0 mg 160.0 mg  Preparation: (1) is triturated with (3). This trituration is added to the mixture of (2) and (4) with vigorous mixing.

This powder mixture is packed into size 3 hard gelatine capsules in a capsule filling machine.

Example VI Capsules Containing 350 mg of Active Substance

Composition:

(1) Active substance 350.0 mg  (2) Dried maize starch 46.0 mg (3) Powdered lactose 30.0 mg (4) Magnesium stearate  4.0 mg 430.0 mg  Preparation: (1) is triturated with (3). This trituration is added to the mixture of (2) and (4) with vigorous mixing.

This powder mixture is packed into size 0 hard gelatine capsules in a capsule filling machine.

Example VII Suppositories Containing 100 mg of Active Substance

1 Suppository Contains:

Active substance 100.0 mg Polyethyleneglycol (M.W. 1500) 600.0 mg Polyethyleneglycol (M.W. 6000) 460.0 mg Polyethylenesorbitan monostearate 840.0 mg 2,000.0 mg  Preparation:

The polyethyleneglycol is melted together with polyethylenesorbitan monostearate. At 40° C. the ground active substance is homogeneously dispersed in the melt. It is cooled to 38° C. and poured into slightly chilled suppository moulds. 

1. A compound of the formula

wherein A denotes a 5- to 7-membered cycloalkyleneimino group wherein a methylene group in the 3 position of a 5-membered cycloalkyleneimino group may be replaced by a sulphur atom, or a methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulphur atom, a sulphinyl or a —NR^(8c)— group and additionally a methylene group adjacent to an above-mentioned —NR^(8c)— group may be replaced by a carbonyl group, a methylene group of the cycloalkyleneimino group may be substituted by one or two C₁₋₄-alkyl groups optionally substituted by a group R^(7a), R^(7b) or R^(7c), or by groups R^(7b) or R^(7c), and/or one or two methylene groups of the cycloalkyleneimino moiety not adjacent to the imino group may be substituted by a group R^(7a), R¹ denotes a hydrogen or halogen atom, a C₁₋₃-alkyl or C₁₋₃-alkoxy group, while the hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly replaced by fluorine atoms, a C₂₋₃-alkenyl, C₂₋₃-alkynyl, nitrile, nitro or amino group, R² denotes a hydrogen or halogen atom or a C₁₋₃-alkyl group, R³ denotes a hydrogen atom or a C₁₋₃-alkyl group, R⁴ and R⁵ in each case independently of one another denote a hydrogen atom, a straight-chain or branched C₁₋₆-alkyl group, while the hydrogen atoms of the straight-chain or branched C₁₋₆-alkyl group may optionally be substituted by a C₁₋₄-alkyloxy, hydroxy, pyridine, or an imidazole group, a phenyl, pyridinyl or imidazolyl, or R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclobutyl, tetrahydrofuranyl, or C₃₋₈-cycloalkyl group, R⁶ denotes a hydrogen, fluorine, chlorine, bromine or iodine atom, a nitrile group, a C₁₋₃-alkyl group, or a C₁₋₃-alkoxy group, while the hydrogen atoms of the C₁₋₃-alkyl or C₁₋₃-alkoxy group may optionally be wholly or partly replaced by fluorine atoms, R^(7a) in each case independently of one another denotes a hydroxy, C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may optionally be wholly or partly replaced by allyloxy, benzyloxy, C₁₋₄-alkylcarbonyloxy, C₁₋₄-alkyloxycarbonyloxy, amino, C₁₋₃-alkylamino, arylamino, heteroarylamino, di-(C₁₋₃-alkyl)-amino, piperidin-4-yl, N—C₁₋₃-alkyl-piperidin-4-yl, N—C₁₋₃-alkylcarbonyl-piperidin-4-yl, C₁₋₅-alkylcarbonylamino, C₁₋₅-alkylsulphonylamino, N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino, C₁₋₅-alkoxycarbonylamino, aminocarbonylamino, C₁₋₄-alkylaminocarbonylamino or a di-(C₁₋₃-alkyl)-aminocarbonylamino group, phenyl, pyridinyl, pyrrolidinyl, R^(7b) in each case independently of one another denotes a carboxy, C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl, C₁₋₄-alkylaminosulphonyl, or di-(C₁₋₄-alkyl)-aminosulphonyl group, R^(7c) in each case independently of one another denotes an aryl or heteroaryl group, R^(8a) in each case independently of one another denotes a C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the hydrogen atoms may optionally be wholly or partly replaced by fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, C₃₋₆-cycloalkyleneimino, carboxy, nitrile, C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl or a di-(C₁₋₃-alkyl)-aminocarbonyl group, R^(8b) in each case independently of one another denotes a hydrogen atom or a C₁₋₅-alkyl group, R^(8c) in each case independently of one another denotes a hydrogen atom, a hydroxyl, C₁₋₅-alkyl, C₁₋₅-alkoxy, formyl, C₁₋₅-alkylcarbonyl, C₁₋₅-alkyloxycarbonyl or C₁₋₅-alkylsulphonyl, aryl or heteroaryl group, which may optionally be substituted by one or two fluorine, chlorine or bromine atom or a group R^(8a), and moreover a phenyl ring optionally substituted by a fluorine, chlorine or bromine atom or a group R^(8a) may be fused to the above-mentioned monocyclic aryl groups via two adjacent carbon atoms, while, unless otherwise stated, by the term “heteroaryl group” mentioned hereinbefore in the definitions is meant a monocyclic 5- or 6-membered heteroaryl group, while the 6-membered heteroaryl group contains one, two or three nitrogen atoms and the 5-membered heteroaryl group contains an imino group optionally substituted by a C₁₋₃-alkyl, phenyl or phenyl-C₁₋₃-alkyl group, an oxygen or sulphur atom or an imino group optionally substituted by a C₁₋₃-alkyl, phenyl, amino-C₂₋₃-alkyl, C₁₋₃-alkyl-amino-C₂₋₃-alkyl, di-(C₁₋₃-alkyl)-amino-C₂₋₃-alkyl, a C₃₋₆-cycloalkyleneimino-C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group or an oxygen or sulphur atom and additionally a nitrogen atom or an optionally by a C₁₋₃-alkyl or phenyl-C₁₋₃-alkyl group substituted imino group and two or three nitrogen atoms, and the above-mentioned monocyclic heteroaryl groups may be substituted in the carbon skeleton by one or two groups R^(8a), and moreover a phenyl ring optionally substituted by a fluorine, chlorine or bromine atom, a C₁₋₃-alkyl, hydroxy, C₁₋₃-alkyloxy group, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino or C₃₋₆-cycloalkyleneimino group may be fused to the above-mentioned monocyclic heteroaryl groups via two adjacent carbon atoms and the bond is effected via a nitrogen atom or a carbon atom of the heterocyclic moiety or a fused-on phenyl ring, while, unless otherwise stated, by the term “halogen atom” mentioned hereinbefore in the definitions is meant an atom selected from among fluorine, chlorine, bromine and iodine, while the alkyl, alkenyl, alkynyl and alkoxy groups contained in the previously mentioned definitions, which have more than two carbon atoms, unless otherwise stated, may be straight-chain or branched and the alkyl groups in the previously mentioned dialkylated groups, for example the dialkylamino groups, may be identical or different, and the hydrogen atoms of the methyl or ethyl groups contained in the foregoing definitions, unless otherwise stated, may be wholly or partly replaced by fluorine atoms, or a tautomer or salt thereof.
 2. A compound of the formula I according to claim 1, wherein: A denotes a 5- to 7-membered cycloalkyleneimino group, wherein a methylene group in the 3 position of a 5-membered cycloalkyleneimino group may be replaced by a sulphur atom, or a methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulphur atom or a —NR^(8c)— group and additionally a methylene group adjacent to an above-mentioned —NR^(8c)— group may be replaced by a carbonyl group, a methylene group of the cycloalkyleneimino group may be substituted by one or two C₁₋₄-alkyl groups optionally substituted by a group R^(7a), R^(7b) or R^(7c), or by groups R^(7b) or R^(7c), and/or one or two methylene groups of the cycloalkyleneimino moiety not adjacent to the imino group may be substituted by a group R^(7a), R¹ denotes a hydrogen, fluorine, chlorine, bromine atom or a methyl or methoxy group, while the hydrogen atoms of the methyl or methoxy group may optionally be wholly or partly replaced by fluorine atoms, R² denotes a hydrogen or fluorine atom, R³ denotes a hydrogen atom, R⁴ denotes a straight-chain or branched C₁₋₃-alkyl group which may optionally be substituted by a C₁₋₂-alkyloxy group, hydroxy, pyridine or an imidazole group, R⁵ denotes a hydrogen atom, or a methyl group, or R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclobutyl, tetrahydrofuranyl, or C₃₋₆-cycloalkyl group, R⁶ denotes a chlorine or bromine atom, R^(7a) in each case independently of one another denotes a hydroxy, C₁₋₄-alkoxy, C₁₋₄-alkylcarbonyloxy, amino, C₁₋₃-alkylamino, phenylamino, di-(C₁₋₃-alkyl)-amino, piperidin-4-yl, N—C₁₋₃-alkyl-piperidin-4-yl, N—C₁₋₃-alkylcarbonyl-piperidin-4-yl, C₁₋₅-alkylcarbonylamino, C₁₋₄-alkylaminocarbonylamino, C₁₋₅-alkylsulphonylamino, N—(C₁₋₅-alkylsulphonyl)-C₁₋₅-alkylamino or C₁₋₅-alkoxycarbonylamino group, R^(7b) in each case independently of one another denotes a C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl, aminosulphonyl, C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, R^(7c) in each case independently of one another denotes an aryl or heteroaryl group, R^(7d) in each case independently of one another denotes a hydroxy, C₁₋₄-alkoxy, while the hydrogen atoms of the C₁₋₄-alkoxy group may optionally be wholly or partly replaced by fluorine atoms, C₁₋₄-alkylcarbonyloxy, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, C₁₋₅-alkylcarbonylamino or C₁₋₅-alkoxycarbonylamino group, R^(7e) in each case independently of one another denotes a C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl, di-(C₁₋₃-alkyl)-aminocarbonyl, nitrile, aminosulphonyl, C₁₋₄-alkylaminosulphonyl or di-(C₁₋₄-alkyl)-aminosulphonyl group, R^(8a) in each case independently of one another denotes a C₁₋₃-alkyl, while the hydrogen atoms may optionally be wholly or partly replaced by fluorine atoms, hydroxy, C₁₋₃-alkyloxy, while the hydrogen atoms may optionally be wholly or partly replaced by fluorine atoms, amino, C₁₋₃-alkylamino, di-(C₁₋₃-alkyl)-amino, nitrile, C₁₋₃-alkylaminocarbonyl or a di-(C₁₋₃-alkyl)-aminocarbonyl group, R^(8c) in each case independently of one another denotes a hydrogen atom, a C₁₋₃-alkyl, C₁₋₃-alkoxy, formyl, C₁₋₃-alkylcarbonyl or C₁₋₄-alkyloxycarbonyl group, while, unless otherwise stated, by the term “aryl group” mentioned hereinbefore in the definitions is meant a phenyl group, which may optionally be substituted by one or two fluorine, chlorine or bromine atoms or a group R^(8a), while the “heteroaryl group” mentioned in the definitions given hereinbefore is selected from the group consisting of imidazolyl, furanyl, oxazolyl, tetrazolyl, pyridinyl, pyrimidinyl and pyrazinyl, while one or two carbon atoms or the NH group contained in 5-membered heteroaryl groups may be substituted by a group R^(8b), while, unless otherwise stated, by the term “halogen atom” mentioned hereinbefore in the definitions is meant an atom selected from among fluorine, chlorine, bromine and iodine, while the alkyl and alkoxy groups contained in the definitions given hereinbefore which have more than two carbon atoms may, unless otherwise stated, be straight-chain or branched and the alkyl groups in the previously mentioned dialkylated groups, for example the dialkylamino groups, may be identical or different, and the hydrogen atoms of the methyl or ethyl groups contained in the foregoing definitions, unless otherwise stated, may be wholly or partly replaced by fluorine atoms, or a tautomer or salt thereof.
 3. A compound of the formula I according to claim 1, wherein: A denotes a 5- to 7-membered cycloalkyleneimino group, wherein a methylene group in the 3 position of a 5-membered cycloalkyleneimino group may be replaced by a sulphur atom, or a methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen or sulphur atom or a —NR^(8c)— group and additionally a methylene group adjacent to an above-mentioned —NR^(8c)— group may be replaced by a carbonyl group, a methylene group of the cycloalkyleneimino group may be substituted by one or two C₁₋₄-alkyl groups optionally substituted by a group R^(7a), R^(7b) or R^(7c), or by groups R^(7b) or R^(7c), and/or one or two methylene groups of the cycloalkyleneimino moiety not adjacent to the imino group may be substituted by a group R^(7a), R¹ denotes a hydrogen, chlorine or bromine atom or a methyl group, R² denotes a hydrogen or fluorine atom, R³ denotes a hydrogen atom, R⁴ denotes a straight-chain or branched C₁₋₃-alkyl group which may optionally be substituted by hydroxy, pyridine, or an imidazole group, R⁵ denotes a hydrogen atom, or a methyl group, or R⁴ and R⁵ together with the carbon atom to which they are bound form a C₃₋₆-cycloalkyl group, cyclobutyl or tetrahydrofuranyl group, R⁶ denotes a chlorine or bromine atom, R^(7a) in each case independently of one another denotes a hydroxy, C₁₋₄-alkoxy, amino, C₁₋₃-alkylamino, phenylamino, di-(C₁₋₃-alkyl)-amino, C₁₋₅-alkylsulphonylamino, or C₁₋₄-alkylaminocarbonylamino group, R^(7b) in each case independently of one another denotes a C₁₋₃-alkoxycarbonyl, aminocarbonyl, C₁₋₃-alkylaminocarbonyl or di-(C₁₋₃-alkyl)-aminocarbonyl group, R^(7c) in each case independently of one another denotes an aryl or heteroaryl group, R^(7d) in each case independently of one another denotes a hydroxy or C₁₋₃-alkoxy group, R^(8c) in each case independently of one another denotes a hydrogen atom, a C₁₋₃-alkyl, formyl, or C₁₋₃-alkylcarbonyl group, while the “heteroaryl group” mentioned in the definitions given hereinbefore is selected from the group consisting of imidazolyl and pyridinyl, while, unless otherwise stated, by the term “halogen atom” mentioned hereinbefore in the definitions is meant an atom selected from among fluorine, chlorine, bromine and iodine, while the alkyl and alkoxy groups contained in the definitions given hereinbefore which have more than two carbon atoms may, unless otherwise stated, be straight-chain or branched and the alkyl groups in the previously mentioned dialkylated groups, for example the dialkylamino groups, may be identical or different, and the hydrogen atoms of the methyl or ethyl groups contained in the foregoing definitions, unless otherwise stated, may be wholly or partly replaced by fluorine atoms, or a tautomer or salt thereof.
 4. A compound of the formula I according to claim 1, wherein R⁴ and R⁵ do not denote hydrogen.
 5. A compound of the formula I according to claim 1, wherein R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclic group.
 6. A compound of the formula I according to claim 1, wherein R⁴ and R⁵ together with the carbon atom to which they are bound form a cyclic group, while in the cyclic group or the corresponding bridged bicyclic group or the spirocyclic group a methylene group is replaced by an oxygen atom or a N(R^(8c)) group according to the specified method.
 7. A compound of the formula I according to claim 1, wherein R⁴ and R⁵ together with the carbon atom to which they are bound denote a cyclic group of the formula


8. A compound of the formula I according to claim 1, wherein: A denotes a 5- to 7-membered cycloalkyleneimino group, where a methylene group of the cycloalkyleneimino moiety may be substituted by a C₁₋₃-alkyl or pyridyl group optionally substituted by a hydroxy, C₁₋₃-alkoxy, di-(C₁₋₃-alkyl)-amino, a 5- to 6-membered cycloalkyleneimino, C₁₋₃-alkylcarbonylamino or C₁₋₃-alkylsulphonylamino group.
 9. A compound of the formula I according to claim 1, wherein: A denotes a 5- to 7-membered cycloalkyleneimino group, while a methylene group in the 4 position of a 6- or 7-membered cycloalkyleneimino group may be replaced by an oxygen atom or by a —NR^(8c)— group and additionally a methylene group adjacent to an above-mentioned —NR^(8c)— group may be replaced by a carbonyl group.
 10. A compound of the formula I according to claim 1, wherein R⁶ denotes a bromine atom.
 11. A compound of the formula I according to claim 1, wherein R⁶ denotes a chlorine atom.
 12. A physiologically acceptable salt of a compound according to any one of claims 1 to
 11. 13. A pharmaceutical composition containing a compound according to claim 1 or a physiologically acceptable salt thereof together with one or more inert carriers and/or diluents.
 14. A compound of the formula I according to claim 1, wherein the 5- to 7-membered cycloalkyleneimino group is selected from the group consisting of pyrrolidine, morpholine, thiomorpholine, piperidine, piperazine, diazepane, azepane and thiazole. 